ArticleFrontiers in immunology2013
T cell aging: a review of the transcriptional changes determined from genome-wide analysis.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Comprehensive flow cytometric reference intervals of leukocyte subsets from six study centers across Europe.Clinical and experimental immunology · 2020Trial
- Inferring cell-specific gene regulatory networks based on causal graph embedding.Cell reports methods · 2026Article
- Mechanistic basis and therapeutic modulation of T cell fitness to enhance CAR-T cell efficacy in hematological malignancies.Frontiers in immunology · 2026Review
- Aging-associated changes in immunological parameters: Implications for COVID-19 immune response in the elderly.Physiological reports · 2025Review
- Epigenetic aging in cows is accelerated by milk production.Epigenetics · 2023Article
- Possibilities of using T-cell biophysical biomarkers of ageing.Expert reviews in molecular medicine · 2022Review
- Aging Phenotypes and Restoring Functional Deficits in Older Adults With Hematologic Malignancy.Journal of the National Comprehensive Cancer Network : JNCCN · 2021Article
- Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells.Frontiers in immunology · 2021Review
- Methods for Characterization of Senescent Circulating and Tumor-Infiltrating T-Cells: An Overview from Multicolor Flow Cytometry to Single-Cell RNA Sequencing.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Evaluating Immune Dysregulation in Patients With COVID-19 Requires a More Accurate Definition of the CD45RA+ T-cell Phenotype.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Single-cell analyses identify dysfunctional CD16Cell reports. Medicine · 2020Article
- CD4The Prostate · 2020Article
- Vaccine-Induced CD8Frontiers in immunology · 2020Review
- Children From the Age of Three Show a Developmental Switch in T-Cell Differentiation.Frontiers in immunology · 2020Article
- Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model.Frontiers in cell and developmental biology · 2020Article
- Changes of T-cell Immunity Over a Lifetime.Transplantation · 2019Review
- Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice.Frontiers in immunology · 2019Article
- Metabolic reprogramming of human CD8The Journal of experimental medicine · 2018Article
- Human T cell immunosenescence and inflammation in aging.Journal of leukocyte biology · 2017Review
- Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.