ArticleFrontiers in endocrinology2013
Differential roles of orexin receptors in the regulation of sleep/wakefulness.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Neuropeptides and the Autonomic Nervous System in Prader-Willi Syndrome.International journal of molecular sciences · 2025Review
- Effects of daridorexant on rest/wake activity patterns and drinking in adult rats exposed to chronic ethanol vapor in adolescence.Alcohol (Fayetteville, N.Y.) · 2025Article
- Hypocretin: a promising target for the regulation of homeostasis.Frontiers in neuroscience · 2025Review
- The effect of lemborexant on insomnia in patients with psychiatric disorders: Detailed evaluation using the Athens Insomnia Scale.PCN reports : psychiatry and clinical neurosciences · 2024Article
- The effects of a dual orexin receptor antagonist on fear extinction memory and sleep in mice: Implications for exposure therapy.Behavioural brain research · 2024Article
- Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation.International journal of molecular sciences · 2024Review
- Dual orexin/hypocretin receptor antagonism attenuates NMDA receptor hypofunction-induced attentional impairments in a rat model of schizophrenia.Behavioural brain research · 2023Article
- Dual orexin/hypocretin receptor antagonism attenuates attentional impairments in an NMDA receptor hypofunction model of schizophrenia.bioRxiv : the preprint server for biology · 2023Article
- Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons.International journal of molecular sciences · 2022Article
- PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence.Psychopharmacology · 2020Article
- Neuropsychiatric Correlates of Narcolepsy.Current psychiatry reports · 2020Review
- Comorbid psychiatric disorders among patients with narcolepsy.Sleep & breathing = Schlaf & Atmung · 2020Article
- Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Narcolepsy and Psychiatric Disorders: Comorbidities or Shared Pathophysiology?Medical sciences (Basel, Switzerland) · 2018Review
- Molecular regulation of hypothalamic development and physiological functions.Molecular neurobiology · 2016Review
- Clinical management of sleep disturbances in Alzheimer's disease: current and emerging strategies.Nature and science of sleep · 2016Review
- Central Disorders of Hypersomnolence: Focus on the Narcolepsies and Idiopathic Hypersomnia.Chest · 2015Review
- Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- Treatment paradigms for cataplexy in narcolepsy: past, present, and future.Nature and science of sleep · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis. The actions of orexins are mediated by two receptors, orexin 1 (OX1R) and orexin 2 (OX2R) receptors. OX1R and OX2R show partly overlapping but distinct distributions throughout the central nervous system, suggesting their differential roles. This review presents and discusses the current knowledge concerning the physiological roles of each orexin receptor subtype, focusing on the regulation of sleep/wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.