ArticleFrontiers in aging neuroscience2013
Metal-induced neurodegeneration in C. elegans.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- Machine Learning-Accelerated Analysis ofResearch square · 2026Article
- A robust, high-content NAM for repeatable and predictive developmental and reproductive toxicity assessment in C. elegans.Scientific reports · 2026Article
- Exploring the neuroprotective, antioxidant, and anti-amyloid effects of Ganoderma lucidum compounds in Alzheimer's disease: insights from experimental and computational approaches.Journal, genetic engineering & biotechnology · 2026Article
- A Robust, High-Content NAM for Repeatable and Predictive Developmental and Reproductive Toxicity Assessment in C. elegans.Research square · 2026Article
- The ionome and proteome landscape of aging in laying hens and relation to egg white quality.Science China. Life sciences · 2023Article
- Applications of a powerful model organism Caenorhabditis elegans to study the neurotoxicity induced by heavy metals and pesticides.Physiological research · 2023Article
- Dietary Transfer of Zinc Oxide Nanoparticles Induces Locomotive Defects Associated with GABAergic Motor Neuron Damage inNanomaterials (Basel, Switzerland) · 2023Article
- The intertwining between lead and ethanol in the model organismFrontiers in toxicology · 2022Review
- Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems inNeuromethods · 2021Article
- Effects of NADBiomolecules · 2020Review
- Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFScientific reports · 2020Article
- Neonicotinoid-containing insecticide disruption of growth, locomotion, and fertility in Caenorhabditis elegans.PloS one · 2020Article
- Review
- Caenorhabditis elegans and its applicability to studies on restless legs syndrome.Advances in pharmacology (San Diego, Calif.) · 2019Review
- Lead (Pb) exposure induces dopaminergic neurotoxicity inToxicology reports · 2019Article
- Toxicity interactions between manganese (Mn) and lead (Pb) or cadmium (Cd) in a model organism the nematode C. elegans.Environmental science and pollution research international · 2018Article
- Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organismMaterials horizons · 2017Article
- Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease inFrontiers in genetics · 2017Review
- Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60-80% of human genes and contain genes involved in metal homeostasis and transport, allowing for the study of metal-induced degeneration in the nematode. This review discusses methods to assess degeneration as well as outlines techniques for genetic manipulation and presents a comprehensive survey of the existing literature on metal-induced degeneration studies in the worm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.