ArticleFrontiers in human neuroscience2013
Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Pooled it
- Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation.Neuroscience and biobehavioral reviews · 2019Pooled it
- The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task.Human brain mapping · 2018Pooled it
- Effects of stress-induced inflammation on reward processing in healthy young women.Brain, behavior, and immunity · 2020Trial
- Distinct midbrain and habenula pathways are involved in processing aversive events in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Getting blood from a stone: Improving brain-behavior inferences without brain data.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Time is Confidence: Monetary Incentives Metacognitive Profile on Duration Judgment.Journal of cognition · 2025Article
- Article
- Resting-State Brain Dynamics Unique to Anxiety in Major Depressive Disorder.Depression and anxiety · 2024Article
- The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study.Neurobiology of stress · 2023Article
- Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.Neuroscience and biobehavioral reviews · 2023Review
- Patterns of demoralization and anhedonia during early substance use disorder treatment and associations with treatment attrition.Journal of affective disorders · 2023Article
- NEURAL RESPONSE TO THREAT AND REWARD AMONG YOUNG ADULTS AT RISK FOR ALCOHOL USE DISORDER.medRxiv : the preprint server for health sciences · 2023Article
- The role of inflammation in acute psychosocial stress-induced modulation of reward processing in healthy female adults.Brain, behavior, & immunity - health · 2023Article
- Exposure to violence is associated with decreased neural connectivity in emotion regulation and cognitive control, but not working memory, networks after accounting for socioeconomic status: a preliminary study.Behavioral and brain functions : BBF · 2022Article
- The Interplay between Reward-Relevant Life Events and Trait Reward Sensitivity in Neural Responses to Reward Cues.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Environmental Contributions to Anhedonia.Current topics in behavioral neurosciences · 2022Review
- Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.Nature communications · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Stress is a significant risk factor for the development of psychopathology, particularly symptoms related to reward processing. Importantly, individuals display marked variation in how they perceive and cope with stressful events, and such differences are strongly linked to risk for developing psychiatric symptoms following stress exposure. However, many questions remain regarding the neural architecture that underlies inter-subject variability in perceptions of stressors. Using functional magnetic resonance imaging (fMRI) during a Monetary Incentive Delay (MID) paradigm, we examined the effects of self-reported perceived stress levels on neural activity during reward anticipation and feedback in a sample of healthy individuals. We found that subjects reporting more uncontrollable and overwhelming stressors displayed blunted neural responses in medial prefrontal cortex (mPFC) following feedback related to monetary gains as well monetary losses. This is consistent with preclinical models that implicate the mPFC as a key site of vulnerability to the noxious effects of uncontrollable stressors. Our data help translate these findings to humans, and elucidate some of the neural mechanisms that may underlie stress-linked risk for developing reward-related psychiatric symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.