ArticleFrontiers in behavioral neuroscience2013
Functional wiring of hypocretin and LC-NE neurons: implications for arousal.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 79 citations in OpenAlex.
- Map-like representations of emotion knowledge in hippocampal-prefrontal systems.Nature communications · 2026Article
- Neural Circuit Connections and Functions of Locus Coeruleus-Norepinephrine System.International journal of molecular sciences · 2025Review
- Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system.Pharmacological reviews · 2025Review
- A ventral pallidum-locus coeruleus-lateral hypothalamus pathway modulates brain arousal in freely behaving and isoflurane-anesthetized male mice.Nature communications · 2025Article
- Quicker Exogenous Orienting and Slower Endogenous Orienting in Autistic People.Journal of autism and developmental disorders · 2025Article
- Hypocretin: a promising target for the regulation of homeostasis.Frontiers in neuroscience · 2025Review
- Intermittent fasting disrupts hippocampal-dependent memory and norepinephrine content in aged male and female mice.Physiology & behavior · 2024Article
- Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure.Research (Washington, D.C.) · 2024Article
- Importance of the locus coeruleus-norepinephrine system in sleep-wake regulation: Implications for aging and Alzheimer's disease.Sleep medicine reviews · 2022Review
- Neuroanatomical Basis for the Orexinergic Modulation of Anesthesia Arousal and Pain Control.Frontiers in cellular neuroscience · 2022Article
- Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System.Current neuropharmacology · 2022Review
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Hypnotics with novel modes of action.British journal of clinical pharmacology · 2020Review
- Neural Circuitry Underlying Waking Up to Hypercapnia.Frontiers in neuroscience · 2019Review
- Neural Circuit Motifs in Valence Processing.Neuron · 2018Review
- Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.Cell reports · 2018Article
- Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Effects of Suvorexant, a Dual Orexin/Hypocretin Receptor Antagonist, on Impulsive Behavior Associated with Cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.Frontiers in neural circuits · 2018Review
- Coupling and dynamics of cortical and autonomic signals are linked to central inhibition during the wake-sleep transition.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To survive in a rapidly changing environment, animals must sense their external world and internal physiological state and properly regulate levels of arousal. Levels of arousal that are abnormally high may result in inefficient use of internal energy stores and unfocused attention to salient environmental stimuli. Alternatively, levels of arousal that are abnormally low may result in the inability to properly seek food, water, sexual partners, and other factors necessary for life. In the brain, neurons that express hypocretin neuropeptides may be uniquely posed to sense the external and internal state of the animal and tune arousal state according to behavioral needs. In recent years, we have applied temporally precise optogenetic techniques to study the role of these neurons and their downstream connections in regulating arousal. In particular, we have found that noradrenergic neurons in the brainstem locus coeruleus (LC) are particularly important for mediating the effects of hypocretin neurons on arousal. Here, we discuss our recent results and consider the implications of the anatomical connectivity of these neurons in regulating the arousal state of an organism across various states of sleep and wakefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.