ArticleClinics in colon and rectal surgery2012
History and pathogenesis of lynch syndrome.
Article in Clinics in colon and rectal surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Review
- Recommended care and care adherence following a diagnosis of Lynch syndrome: a mixed-methods study.Hereditary cancer in clinical practice · 2019Article
- Rectal Cancer Diagnosed after Cesarean Section in Which High Microsatellite Instability Indicated the Presence of Lynch Syndrome.Case reports in obstetrics and gynecology · 2015Article
- Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome.World journal of gastroenterology · 2014Article
- Is there a role for impaired DNA mismatch repair system in the pathogenesis of ameloblastomas? A scoping review.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lynch syndrome is the familial clustering of colorectal and endometrial cancers. This syndrome is passed in an autosomal dominant fashion within families with defective mismatch repair as the genetic basis for cancer development in these patients. There remains a group of patients who fit clinical diagnostic criteria for an autosomal dominant familial cancer syndrome, which is phenotypically similar to Lynch syndrome, but for which no mismatch repair mutation is identified. Identification of alternate genetic mutations such as EPCAM and CHEK2 may explain the cancer risk in a small subset of these patients, but continuing work into the genetic basis of colorectal familial cancer syndromes is needed.
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