ArticleNutrition and dietary supplements2010
Role of grape seed polyphenols in Alzheimer's disease neuropathology.
Article in Nutrition and dietary supplements, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Bioactive dietary polyphenols modulate hippocampal inflammasome activation and sex-specific affective behavioral deficits following peripheral Foxp3Research square · 2026Article
- Exploring the Neuroprotective Effects of Grape Seed Procyanidins on Amyloid-β-Induced Toxicity inFoods (Basel, Switzerland) · 2024Article
- Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Review
- Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity.Molecules (Basel, Switzerland) · 2022Review
- Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders.Computational and structural biotechnology journal · 2022Review
- Grapevine as a Rich Source of Polyphenolic Compounds.Molecules (Basel, Switzerland) · 2020Review
- Article
- Relationship of Wine Consumption with Alzheimer's Disease.Nutrients · 2020Review
- The Effect of Polyphenols on Protein Degradation Pathways: Implications for Neuroprotection.Molecules (Basel, Switzerland) · 2017Review
- Masquelier's grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits.Nutrition journal · 2017Review
- Polyphenol compounds and PKC signaling.Biochimica et biophysica acta · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative condition characterized by a progressive decline in cognitive function. AD affects approximately five million people in the US, creating a devastating financial burden on health care costs and an emotional burden on caregivers. To date, there is no cure for AD, so researchers are continually exploring novel avenues for the prevention and treatment of this condition. In this article, we present some findings from our laboratory and those of others on the potential benefits of a grape seed polyphenolic extract (GSPE) for the prevention and treatment of AD, including its chemical composition, bioactivity, bioavailability, safety, and tolerability, and the mechanisms by which it interferes with AD pathogenesis. Findings presented in this review article support the development of GSPE as a preventative and/or therapeutic agent in AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.