ArticleSeminars in interventional radiology2012
Update on islet cell transplantation for type 1 diabetes.
Article in Seminars in interventional radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Active targeting of type 1 diabetes therapies to pancreatic beta cells using nanocarriers.Diabetologia · 2025Review
- Article
- Pancreas transplant in type 1 diabetes mellitus: the emerging role of islet cell transplant.Annals of pediatric endocrinology & metabolism · 2021Article
- Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1Stem cell research & therapy · 2021Article
- Bioprinting an Artificial Pancreas for Type 1 Diabetes.Current diabetes reports · 2019Review
- Applications of stem cells and bioprinting for potential treatment of diabetes.World journal of stem cells · 2019Review
- Redox-Dependent Inflammation in Islet Transplantation Rejection.Frontiers in endocrinology · 2018Review
- Type 1 diabetes: where are we in 2017?Translational pediatrics · 2017Review
- Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.Cell transplantation · 2017Article
- Single-donor islet transplantation in type 1 diabetes: patient selection and special considerations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
- Infectious complications of pancreatic islet transplantation: clinical experience and unanswered questions.Current infectious disease reports · 2015Article
- Mesenchymal stem cells in the treatment of type 1 diabetes mellitus.Endocrine pathology · 2015Review
- Article
- Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
- Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model.Biomaterials · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite modern medical breakthroughs, diabetes mellitus is a worldwide leading cause of morbidity and mortality. Definitive surgical treatment of diabetes mellitus was established with the advent and refinement of clinical pancreas transplantation in the 1960s. During the following decades, critical discoveries involving islet isolation and engraftment took place. Clinical islet cell transplantation represents the potential for reduced insulin requirements and debilitating hypoglycemic episodes without the morbidity of surgery. Unfortunately, islet cell transplantation was unable to achieve comparable results with solid organ transplantation. This was until the Edmonton protocol (steroid-free immunosuppression) was described, which demonstrated that islet cell transplantation could be a viable alternative to pancreas transplantation. Significant advances in islet purification techniques and novel immunomodulatory agents have since renewed interest in islet cell transplantation. Yet the field is still challenged by a limited supply of islet cells, inadequate engraftment, and the deleterious effects of chronic immunosuppression. This article discusses the history and the current status of clinical islet cell transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.