ArticleClinical and experimental immunology1990
Oestrogen is a potent disease accelerator in SLE-prone MRL lpr/lpr mice.
Article in Clinical and experimental immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 143 citations in OpenAlex.
- Treatment for insomnia in combat-exposed OEF/OIF/OND military veterans: preliminary randomized controlled trial.Behaviour research and therapy · 2014Trial
- Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.Cell reports · 2026Article
- Increased development of T-betClinical immunology (Orlando, Fla.) · 2023Article
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- Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.Frontiers in immunology · 2019Article
- Complete knockout of estrogen receptor alpha is not directly protective in murine lupus.Clinical immunology (Orlando, Fla.) · 2017Article
- Early Ovariectomy Results in Reduced Numbers of CD11c+/CD11b+ Spleen Cells and Impacts Disease Expression in Murine Lupus.Frontiers in immunology · 2016Article
- Modulation of autoimmune rheumatic diseases by oestrogen and progesterone.Nature reviews. Rheumatology · 2014Review
- Does estrogen deficiency cause lacrimal gland inflammation and aqueous-deficient dry eye in mice?Experimental eye research · 2014Article
- 17β-Estradiol protects against the progression of hypertension during adulthood in a mouse model of systemic lupus erythematosus.Hypertension (Dallas, Tex. : 1979) · 2014Article
- 17-β Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice.Atherosclerosis · 2013Article
- The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.Annals of the rheumatic diseases · 2012Article
- IL-6 contributes to an immune tolerance checkpoint in post germinal center B cells.Journal of autoimmunity · 2012Article
- The MRL/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2011Review
- Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus.Lupus · 2010Article
- The role of B cells in lupus pathogenesis.The international journal of biochemistry & cell biology · 2010Review
- Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta.Arthritis research & therapy · 2010Article
- Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse.Clinical immunology (Orlando, Fla.) · 2008Article
- Behavioral heterogeneity in an animal model of neuropsychiatric lupus.Biological psychiatry · 2005Article
- Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of oestrogen on the lupus disease in MRL/l mice has been investigated. Adult, castrated male and female MRL/l mice were administered with s.c. injections of 3.2 micrograms of 17 beta-oestradiol twice a week. The results clearly demonstrate that a relatively small dose of oestrogen is a potent accelerator of the lupus disease in this mouse strain. Thus, administration of oestrogen accelerates glomerulonephritis, lymphoproliferation and mortality. Our results also indicate that oestrogen exerts a dual effect on the immune system of MRL/l mice by depression of antigen-specific and mitogen-induced T cell responses as well as enhancement of polyclonal B cell activation and autoantibody formation. In addition, even short-term administration of oestrogen in the preclinical phase of the disease resulted in long-lasting effects as evaluated by reduced longevity and aggravation of renal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.