ArticleSleep2013
Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02832336 (The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Caffeine on the Narcoleptic Patients Randomized Controlled Clinical Trial
Who cites it
47 citing papers in PubMed.
- Changes in Cataplexy Frequency in a Clinical Trial of Lower-Sodium Oxybate with Taper and Discontinuation of Other Anticataplectic Medications.CNS drugs · 2022Trial
- Mortality in narcolepsy and other sleep clinic patients: a 25-year propensity-matched VA cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Chronic pain in narcolepsy reflects interacting neurobiological and psychological mechanisms: a mini-review.Frontiers in sleep · 2026Review
- Article
- Present and Future of Central Disorders of Hypersomnolence.Journal of sleep research · 2025Review
- All-Cause and Cause-Specific Mortality Among Patients With Narcolepsy.JAMA network open · 2025Article
- RLS shows increased resting state sympathetic activity and decreased sympathetic response capability.Journal of neurology · 2025Article
- Global estimates of vaccine-associated narcolepsy from 1967 to 2023.Scientific reports · 2025Article
- Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map.Journal of sleep research · 2025Article
- Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025Review
- Narcolepsy: Beyond the Classic Pentad.CNS drugs · 2025Review
- Comorbidity of obstructive sleep apnea and narcolepsy: A challenging diagnosis and complex management.Sleep medicine: X · 2024Review
- Relationship Between Sleep Disturbances and Chronic Pain: A Narrative Review.Clinics and practice · 2024Review
- Narcolepsy and risk of traumatic injury: a population-based matched cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Psychiatric comorbidity in Danish patients with narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a case-control study.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- What respiratory physicians should know about narcolepsy and other hypersomnias.Breathe (Sheffield, England) · 2022Review
- Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022Review
- Association between sleep duration and chest pain in US adults: A cross-sectional study.Frontiers in public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo identify the factual morbidity and mortality of narcolepsy in a controlled design.
settingNational Patient Registry. PATIENTS: All national diagnosed patients (757) with health information at least 3 years prior to and after diagnose of narcolepsy. CONTROLS: Randomly selected four citizens (3,013) matched for age, sex, and socioeconomic status from the Danish Civil Registration System Statistics.
resultsIncreased morbidity prior to narcolepsy diagnosis included (odds ratio, 95% confidence interval):- diseases of the endocrine, nutritional, and metabolic systems (2.10, 1.32-3.33); nervous system (5.27, 3.65-7.60); musculoskeletal system (1.59, 1.23-2.05); and other abnormal symptoms and laboratory findings (1.66, 1.25-2.22). After the diagnosis, narcolepsy patients experienced diseases of the endocrine, nutritional, and metabolic (2.31, 1.51-3.54), nervous (9.19, 6.80-12.41), musculoskeletal (1.70, 1.28-2.26), eye (1.67, 1.03-2.71), and respiratory systems (1.84, 1.21-2.81). Specific diagnoses were diabetes (2.4, 1,2-4.7, P < 0.01), obesity (13.4, 3.1-57.6, P < 0.001), sleep apnea (19.2, 7.7-48.3, P < 0.001), other sleep disorders (78.5, 11.8-523.3, P < 0.001), chronic obstructive pulmonary disease (2.8, 1.4-5.8, P < 0.01), lower back pain (2.5, 1.4-4.2, P < 0.001), arthrosis/arthritis (2.5, 1.3-4.8, P < 0.01), observation of neurological diseases (3.5, 1.9-6.5, P < 0.001), observation of other diseases (1.7, 1.2-2.5, P < 0.01), and rehabilitation (5.0, 1.5-16.5, P < 0.005). There was a trend towards greater mortality in narcolepsy (P = 0.07).
conclusionsPatients with narcolepsy present higher morbidity several years prior to diagnose and even higher thereafter. The mortality rate due to narcolepsy was slightly but not significantly higher.
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Registered trials
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