ArticleJournal of biological physics2012
A mathematical model of the tripartite synapse: astrocyte-induced synaptic plasticity.
Article in Journal of biological physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Interdependence of cytosolic and mitochondrial calcium dynamics in a hepatocyte cell due to obesity.Journal of biosciences · 2026Article
- A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex.Journal of mathematical biology · 2025Article
- Astrocyte-mediated neuronal irregularities and dynamics: the complexity of the tripartite synapse.Biological cybernetics · 2024Article
- Numerical simulation of calcium dynamics dependent ATP degradation, IPJournal of biological physics · 2023Article
- To study the effect of ER flux with buffer on the neuronal calcium.European physical journal plus · 2023Article
- Probing microdomain CaFrontiers in network physiology · 2023Article
- Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD.Frontiers in molecular neuroscience · 2022Review
- Ion dynamics at the energy-deprived tripartite synapse.PLoS computational biology · 2021Article
- Modeling of Astrocyte Networks: Toward Realistic Topology and Dynamics.Frontiers in cellular neuroscience · 2021Article
- A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics.Frontiers in cellular neuroscience · 2021Article
- Spatiotemporal model of tripartite synapse with perinodal astrocytic process.Journal of computational neuroscience · 2020Article
- Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity.Frontiers in physiology · 2019Article
- Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- A Compartmental Model to Investigate Local and Global CaFrontiers in computational neuroscience · 2018Article
- Computational simulation: astrocyte-induced depolarization of neighboring neurons mediates synchronous UP states in a neural network.Journal of biological physics · 2015Article
- Astrocytes Modulate Local Field Potential Rhythm.Frontiers in integrative neuroscience · 2015Article
- Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders.Journal of signal transduction · 2014Review
- Data and model tango to aid the understanding of astrocyte-neuron signaling.Frontiers in computational neuroscience · 2014Article
- A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework.Frontiers in computational neuroscience · 2013Article
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2 authors.
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Abstract
In this paper, we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and a peri-synaptic astrocyte controlling Ca(2 + ) dynamics inside the synaptic bouton. This in turn controls glutamate release dynamics in the cleft. As a consequence of this, glutamate concentration in the cleft has been modeled, in which glutamate reuptake by astrocytes has also been incorporated. Finally, dendritic spine-head dynamics has been modeled. As an application, this model clearly shows synaptic potentiation in the hippocampal region, i.e., astrocyte Ca(2 + ) mediates synaptic plasticity, which is in conformity with the majority of the recent findings (Perea and Araque (Science 317, 1083-1086, 2007); Henneberger et al. (Nature 463, 232-236, 2010); Navarrete et al. (PLoS Biol. 10, e1001259, 2012)).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.