ArticleComputers & structures2013
Coupled Particulate and Continuum Model for Nanoparticle Targeted Delivery.
Article in Computers & structures, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- From Blood Flow to Tumor Cell Internalization: A Multistage Computational Model of Nanoparticle Dynamics.Pharmaceutical research · 2026Article
- Rational nanoparticle design: Optimization using insights from experiments and mathematical models.Journal of controlled release : official journal of the Controlled Release Society · 2023Review
- Targeted pulmonary drug delivery in coronavirus disease (COVID-19) therapy: A patient-specific in silico study based on magnetic nanoparticles-coated microcarriers adhesion.International journal of pharmaceutics · 2021Article
- Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery.Current opinion in structural biology · 2020Review
- Multiscale modeling of hemolysis during microfiltration.Microfluidics and nanofluidics · 2020Article
- Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels.Beilstein journal of nanotechnology · 2020Article
- Label-free sorting of soft microparticles using a bioinspired synthetic cilia array.Biomicrofluidics · 2018Article
- Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods.Physical review. E · 2018Article
- A Cellular Model of Shear-Induced Hemolysis.Artificial organs · 2017Article
- Multiscale Modeling in the Clinic: Drug Design and Development.Annals of biomedical engineering · 2016Review
- Highly efficient and selective isolation of rare tumor cells using a microfluidic chip with wavy-herringbone micro-patterned surfaces.The Analyst · 2016Article
- Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium.Bioengineering & translational medicine · 2016Article
- Characterization of Nanoparticle Dispersion in Red Blood Cell Suspension by the Lattice Boltzmann-Immersed Boundary Method.Nanomaterials (Basel, Switzerland) · 2016Article
- Numerical simulation of particle transport and deposition in the pulmonary vasculature.Journal of biomechanical engineering · 2014Article
- Characterization of nanoparticle delivery in microcirculation using a microfluidic device.Microvascular research · 2014Article
- Computational modeling of magnetic nanoparticle targeting to stent surface under high gradient field.Computational mechanics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Prediction of nanoparticle (NP) distribution in a vasculature involves transport phenomena at various scales and is crucial for the evaluation of NP delivery efficiency. A combined particulate and continuum model is developed to model NP transport and delivery processes. In the particulate model ligand-receptor binding kinetics is coupled with Brownian dynamics to study NP binding on a microscale. An analytical formula is derived to link molecular level binding parameters to particulate level adhesion and detachment rates. The obtained NP adhesion rates are then coupled with a convection-diffusion-reaction model to study NP transport and delivery at macroscale. The binding results of the continuum model agree well with those from the particulate model. The effects of shear rate, particle size and vascular geometry on NP adhesion are investigated. Attachment rates predicted by the analytical formula also agree reasonably well with the experimental data reported in literature. The developed coupled model that links ligand-receptor binding dynamics to NP adhesion rate along with macroscale transport and delivery processes may serve as a faster evaluation and prediction tool to determine NP distribution in complex vascular networks.
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Registered trials
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