CrossTalk proposal: there is added benefit to providing permissive hypercapnia in the treatment of ARDS.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis.Intensive care medicine · 2022
   Pooled it
2. Acute Respiratory Distress Syndrome, Mechanical Ventilation, and Inhalation Injury in Burn Patients.The Surgical clinics of North America · 2023
   Review
3. Hypercapnia from Physiology to Practice.International journal of clinical practice · 2022
   Review
4. The role of hypercapnia in acute respiratory failure.Intensive care medicine experimental · 2019
   Review
5. Effect of continuous dialysis on blood ph in acidemic hypercapnic animals with severe acute kidney injury: a randomized experimental study comparing high vs. low bicarbonate affluent.Intensive care medicine experimental · 2017
   Article
6. Hypercapnia during acute respiratory distress syndrome: the tree that hides the forest!Journal of thoracic disease · 2017
   Article
7. Year in review 2013: Critical Care--respirology.Critical care (London, England) · 2014
   Review
8. Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17.The Journal of physiology · 2014
   Article
9. Carbon dioxide-sensing in organisms and its implications for human disease.Cellular and molecular life sciences : CMLS · 2014
   Review
10. Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra.The Journal of physiology · 2013
    Article

Corrections and comments

• Commented on by
  CrossTalk opposing view: there is not added benefit to providing permissive hypercapnia in the treatment of ARDS.2013
• Commented on by
  Rebuttal from Gerard F. Curley, John G. Laffey and Brian P. Kavanagh.2013

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as