ArticlePlant physiology2013
A common fungal associate of the spruce bark beetle metabolizes the stilbene defenses of Norway spruce.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Fungal backpackers-the mycobiome ofFrontiers in microbiology · 2025Pooled it
- Bark and ambrosia beetle fungi emit a greater diversity of volatile organic compounds than other fungi.FEMS microbiology ecology · 2026Article
- AcWRKY75 and AcMYB108 mediated ABA-GA antagonism in the regulation of pineapple internal browning.Molecular horticulture · 2026Article
- Amplicon-Based Profiling of Fungal Communities Associated with Scots Pine Bark Beetles: Selective Antagonism and Monoterpene Tolerance.International journal of molecular sciences · 2026Article
- From beginning to end: the synecology of tree-killing bark beetles, fungi, and trees.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Fungi associated with Norway spruce and its bark beetles detoxify spruce defense compounds by conjugation to α-ribose.The ISME journal · 2026Article
- The mutualistic fungi of the bark beetleISME communications · 2026Article
- FAMeDB: A Curated Database for the Analysis of Fungal Aromatic Compound Metabolism.Computational and structural biotechnology journal · 2026Article
- Phytoplasma infection renders cranberries more susceptible to above- and belowground insect herbivores.Insect science · 2025Article
- Distinct assembly processes of intestinal and non-intestinal microbes of bark beetles from clues of metagenomic insights.Scientific reports · 2025Article
- Insights into the Detoxification of Spruce Monoterpenes by the Eurasian Spruce Bark Beetle.International journal of molecular sciences · 2024Article
- In Situ Antimicrobial Properties of Sabinene Hydrate, a Secondary Plant Metabolite.Molecules (Basel, Switzerland) · 2024Article
- Impact of intraspecific variation in insect microbiomes on host phenotype and evolution.The ISME journal · 2023Review
- Odors Attracting the Long-Legged Predator Medetera signaticornis Loew to Ips typographus L. Infested Norway Spruce Trees.Journal of chemical ecology · 2023Article
- Impact of Wood Age on Termite Microbial Assemblages.Applied and environmental microbiology · 2023Article
- Wood Degradation byJournal of fungi (Basel, Switzerland) · 2023Article
- Review
- Article
- Conifer-killing bark beetles locate fungal symbionts by detecting volatile fungal metabolites of host tree resin monoterpenes.PLoS biology · 2023Article
- First genome-scale insights into the virulence of the snow mold causal fungus Microdochium nivale.IMA fungus · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Norway spruce (Picea abies) forests suffer periodic fatal attacks by the bark beetle Ips typographus and its fungal associate, Ceratocystis polonica. Norway spruce protects itself against fungal and bark beetle invasion by the production of terpenoid resins, but it is unclear whether resins or other defenses are effective against the fungus. We investigated stilbenes, a group of phenolic compounds found in Norway spruce bark with a diaryl-ethene skeleton with known antifungal properties. During C. polonica infection, stilbene biosynthesis was up-regulated, as evidenced by elevated transcript levels of stilbene synthase genes. However, stilbene concentrations actually declined during infection, and this was due to fungal metabolism. C. polonica converted stilbenes to ring-opened, deglycosylated, and dimeric products. Chromatographic separation of C. polonica protein extracts confirmed that these metabolites arose from specific fungal enzyme activities. Comparison of C. polonica strains showed that rapid conversion of host phenolics is associated with higher virulence. C. polonica is so well adapted to its host's chemical defenses that it is even able to use host phenolic compounds as its sole carbon source.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.