ReviewReviews in the neurosciences2013
Prefrontal dopamine signaling and cognitive symptoms of Parkinson's disease.
Review in Reviews in the neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Polychlorinated biphenyls (PCBs) exposure and cognitive function in adults: A systematic review of epidemiologic evidence and risk of bias assessment.Neurotoxicology · 2026Pooled it
- Efficacy of non-invasive neuromodulation technologies in improving cognitive function and activities of daily living in patients with Alzheimer's disease, Parkinson's disease, and stroke: a systematic review and network meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.Behavioral neuroscience · 2022Pooled it
- Early use of donepezil against psychosis and cognitive decline in Parkinson's disease: a randomised controlled trial for 2 years.Journal of neurology, neurosurgery, and psychiatry · 2018Trial
- Imaging analysis of Parkinson's disease patients using SPECT and tractography.Scientific reports · 2016Trial
- Analysis of clinical trials on drugs targeting dopamine receptors: a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Stimulus-Evoked Brain Signals for Parkinson's Detection: A Comprehensive Benchmark Performance Analysis on Cross-Stimulation and Channel-Wise Experiments.Bioengineering (Basel, Switzerland) · 2025Article
- VNTR Polymorphisms in theBioengineering (Basel, Switzerland) · 2025Article
- Sorghum bicolor supplement attenuates rotenone-induced behavioral derangements in rats through neuroprotective mechanisms and modulation of tyrosine hydroxylase and α-synuclein/NF-kB immunopositive cells expressions.Journal of molecular histology · 2025Article
- Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- HIV-1 Tat protein alters medial prefrontal cortex neuronal activity and recognition memory.iScience · 2025Article
- Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain.Acta neuropathologica communications · 2025Article
- Attentional dysfunction arises from right frontocentral and occipital network connectivity in Parkinson's disease.Neuroimage. Reports · 2025Article
- NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson's disease-like phenotypes in mice.Molecular neurodegeneration · 2024Article
- Naturalistic assessment of everyday multitasking in Parkinson's disease with and without mild cognitive impairment.The Clinical neuropsychologist · 2024Article
- Enhancing early Parkinson's disease detection through multimodal deep learning and explainable AI: insights from the PPMI database.Scientific reports · 2024Article
- Mouse Model of Parkinson's Disease with Bilateral Dorsal Striatum Lesion with 6-Hydroxydopamine Exhibits Cognitive Apathy-like Behavior.International journal of molecular sciences · 2024Article
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
- Impaired value-based decision-making in Parkinson's disease apathy.Brain : a journal of neurology · 2024Article
- The Effect of Upright Stance and Vision on a Cognitive Task in Elderly Subjects and Patients with Parkinson's Disease.Brain sciences · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive dysfunction is a common symptom of Parkinson's disease (PD) that causes significant morbidity and mortality. The severity of these symptoms ranges from minor executive symptoms to frank dementia involving multiple domains. In the present review, we will concentrate on the aspects of cognitive impairment associated with prefrontal dopaminergic dysfunction, seen in non-demented patients with PD. These symptoms include executive dysfunction and disorders of thought, such as hallucinations and psychosis. Such symptoms may go on to predict dementia related to PD, which involves amnestic dysfunction and is typically seen later in the disease. Cognitive symptoms are associated with dysfunction in cholinergic circuits, in addition to the abnormalities in the prefrontal dopaminergic system. These circuits can be carefully studied and evaluated in PD, and could be leveraged to treat difficult clinical problems related to cognitive symptoms of PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.