ArticleInflammation2013
Therapeutic effect of emodin on collagen-induced arthritis in mice.
Article in Inflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Emodin ameliorates renal injury and fibrosisFrontiers in pharmacology · 2023Article
- Natural emodin reduces myocardial ischemia/reperfusion injury by modulating the RUNX1/miR‑142‑3p/DRD2 pathway and attenuating inflammation.Experimental and therapeutic medicine · 2022Article
- Review
- Mechanism of Emodin in the Treatment of Rheumatoid Arthritis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Obtusifolin, an Anthraquinone Extracted fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Emodin Improves Glucose and Lipid Metabolism Disorders in Obese MiceFrontiers in endocrinology · 2021Article
- Chemical Composition ofFrontiers in pharmacology · 2020Article
- Could Polyphenols Help in the Control of Rheumatoid Arthritis?Molecules (Basel, Switzerland) · 2019Review
- Effect of emodin on chondrocyte viability in anExperimental and therapeutic medicine · 2018Article
- Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation.Oxidative medicine and cellular longevity · 2017Article
- Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics.Phytotherapy research : PTR · 2016Review
- The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring.Burns & trauma · 2016Review
- Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats.International journal of ophthalmology · 2015Article
- Protective Mechanisms of Flavonoids in Parkinson's Disease.Oxidative medicine and cellular longevity · 2015Review
- Anti-inflammatory effect of emodin on lipopolysaccharide-induced keratitis in Wistar rats.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emodin, an anthraquinone isolated from the Chinese herb Radix et Rhizoma Rhei, has been reported to have anti-inflammatory, antibacterial, and antitumor activities. However, the effect of emodin on collagen-induced arthritis (CIA) has not yet been investigated. The purpose of this study was to investigate whether emodin has a protective effect against collagen-induced arthritis in mice and its possible mechanisms. CIA was induced in mice by immunization with bovine type II collagen. The mice were treated with emodin (5, 10, and 20 mg/kg/day, i.g.) from days 21 to 42 after immunization. The clinical scores and hind paw swelling were evaluated. The expression of prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2) in synovial tissues was determined. The levels of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in the plasma were measured by enzyme-linked immunosorbent assay. The results showed that emodin treatment significantly alleviated the severity of the disease, based on the reduced hind paw swelling and clinical scores, compared with untreated CIA mice. Comparing with untreated CIA mice, emodin treatment inhibited the levels of TNF-α and IL-6 in the plasma, PGE2 production, and COX-2 protein expression in synovial tissues in a dose manner. In conclusion, our results suggest that anti-inflammatory effects of emodin against collagen-induced arthritis in mice may be due to its ability to inhibit pro-inflammatory mediators. Emodin may be a promising potential therapeutic reagent for arthritis treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.