Evidence map›Paper›PMID 23729167›Full record

ReviewEndocrine2013

Role of T cells in the modulation of PTH action: physiological and clinical significance.

Roberto Pacifici

Abstract readReview
In one paragraph

Review in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. FZD6 triggers Wnt-signalling driven by WNT10BHematological oncology · 2021
    Article
  7. Article
  8. Article
  9. CD8Inflammation · 2018
    Article
  10. Regulation of Bone Remodeling by Parathyroid Hormone.Cold Spring Harbor perspectives in medicine · 2018
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Advances in treatment of glucocorticoid-induced osteoporosis.Current opinion in endocrinology, diabetes, and obesity · 2017
    Review
  16. Bone and the Immune System.Toxicologic pathology · 2017
    Review
  17. CD8Frontiers in immunology · 2017
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Roberto PacificiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Room 1309, Atlanta, GA, 30322, USA, roberto.pacifici@emory.edu.
Emory University · US

Funding

T CELLS AND PTH INDUCED BONE LOSSR01AR054625 · NIAMS · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2007 to 2016
$3.3M
Regulation of T Cell TNF ProductionR01AR049659 · NIAMS · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2002 to 2012
$2.8M
Regulation of hemopoietic stem cell expansion by calciotrophic hormonesR01DK091780 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2011 to 2014
$1.5M
NIAMS NIH HHS R01 AR049659NIAMS NIH HHS R01 AR054625NIDDK NIH HHS R01 DK091780
6 · The paper itself

Abstract

Osteoimmunology is new field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone and hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells, one of which is Wnt10b. This article will review the evidence that T cells are implicated in the mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.

Indexed as

Bone and BonesCytokinesHumansImmune SystemOsteogenesisParathyroid HormoneT-LymphocytesCytokinesParathyroid Hormone

Identifiers

PMID23729167
PMCPMC3815684
OpenAlexW2004857322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.