ArticleCirculation. Cardiovascular genetics2013
Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk.
Article in Circulation. Cardiovascular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population.Diagnostics (Basel, Switzerland) · 2024Article
- Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus.Frontiers in endocrinology · 2024Review
- Disease patterns of coronary heart disease and type 2 diabetes harbored distinct and shared genetic architecture.Cardiovascular diabetology · 2022Article
- Article
- Association between rs3088440 (G > A) polymorphism at 9p21.3 locus with the occurrence and severity of coronary artery disease in an Iranian population.Molecular biology reports · 2021Article
- Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease.Circulation research · 2020Review
- Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers.Biomolecules · 2019Article
- Mediating Effect of Diabetes Mellitus on the Association Between Chromosome 9p21.3 Locus and Myocardial Infarction Risk: A Case-Control Study in Shanghai, China.Frontiers in endocrinology · 2018Article
- The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism.Journal of Taibah University Medical Sciences · 2017Review
- Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice.Circulation. Cardiovascular genetics · 2016Article
- 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?Current cardiology reports · 2014Review
- Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease.Current cardiovascular risk reports · 2014Article
- Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies.PloS one · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVariants at the 9p21 locus associate with the risk of coronary artery disease (CAD) or myocardial infarction (MI). However, atherosclerotic plaque deposition is distinct from MI (plaque rupture and thrombosis), and recent studies showed no association between these variants and MI in patients with preexisting CAD. We performed haplotype analysis at the 9p21 locus to test whether haplotypes at distinct linkage disequilibrium blocks predict these phenotypes. METHODS AND
resultsUsing 24 single-nucleotide polymorphisms genotyped in white patients without diabetes mellitus, we reconstructed haplotypes at the 9p21 locus. Patients with angiograhic CAD/MI had ≥1 epicardial stenosis >50% (n=2352), whereas controls were asymptomatic and over the age of 60 years (n=2116). For CAD patients, regression models examined the association of haplotypes with initial age of symptomatic CAD, number of diseased vessels, and history of MI. In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI. These haplotypes also associated with early onset of CAD (β=-0.13; P=1.37×10(-4)) and disease severity (β=0.1823; P=0.006) but not with prevalent MI among patients with CAD. In contrast, haplotypes at another block tagged by rs518394 associated with prevalent MI (β=0.239; P=2.05×10(-4)), but remarkably these are inversely associated with disease severity (β=-0.196; P=0.003). This MI association was replicated in the Cleveland Clinic GeneBank premature CAD cohort (n=1385; β=0.207; P=0.019).
conclusionsVariants/haplotypes at 2 blocks are distinguished at 9p21; those at 1 block predispose to atherosclerosis, whereas those at the other predispose to MI among patients with preexisting CAD.
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