ReviewComprehensive Physiology2012
Peripheral chemoreceptors: function and plasticity of the carotid body.
Review in Comprehensive Physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
305 citing papers in PubMed.
- Pioglitazone does not enhance exogenous glucose oxidation or metabolic clearance rate during aerobic exercise in men under acute high-altitude exposure.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Trial
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge.PloS one · 2020Trial
- Carotid chemoreflex activity restrains post-exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension.The Journal of physiology · 2019Trial
- Effects of normobaric hypoxia and hyperthermia on ventilatory responses to high-intensity interval training bouts.European journal of applied physiology · 2026Article
- The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.Brain, behavior, & immunity - health · 2026Review
- Carotid body dysfunction contributes to respiratory instability in Rett syndrome.Current biology : CB · 2026Article
- Physiology-guided mechanical ventilation: Monitoring, proportional assist, and bounded automation.World journal of critical care medicine · 2026Review
- The Takotsubo Syndrome: Where the Sympathetic Stress Reflex and the Dive Reflex Conflict.Cureus · 2026Article
- PRBS Gas Challenges Reveal Impaired Chemoreflex and Cholinergic Dynamics in MCI.Annals of biomedical engineering · 2026Article
- Carotid body hypoxia induces angiogenesis and correlates with glomic artery anatomy and carotid artery atherosclerosis.iScience · 2026Article
- Carotid body measurement by computed tomography angiography: a cross-sectional population-based study.BMC medical imaging · 2026Article
- Emotional Coherence Under Hypoxia and Aging: A Registered Report on Subjective-Physiological Coupling.Psychophysiology · 2026Article
- Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.Current hypertension reports · 2026Review
- Effects of Continuous Positive Airway Pressure for Hypertension in Patients with Obstructive Sleep Apnoea: A Structured Narrative Review of Randomised Controlled Trials.Journal of clinical medicine · 2026Review
- Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026Article
- Maximal strength and voluntary activation of adductor pollicis after a single session of acute intermittent hypercapnia or acute intermittent hypoxia.Experimental physiology · 2026Article
- Intracellular calcium release activates carotid body afferents by fentanyl.Function (Oxford, England) · 2026Article
- Carbon Dioxide Inhalation-Risks for Health or Opportunity for Physical Fitness Development?Journal of clinical medicine · 2026Review
- Physiology of nitrogen: A life or death matter.Experimental physiology · 2026Review
245 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus-response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood-borne stimuli, including reduced glucose and immune-related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.