ArticleCurrent microbiology2013
Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying bla KPC-2 in a Klebsiella pneumoniae.
Article in Current microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 49 citations in OpenAlex.
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- Carbapenemase ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Apramycin resistance in epidemic carbapenem-resistant Klebsiella pneumoniae ST258 strains.The Journal of antimicrobial chemotherapy · 2021Article
- Combining Functional Genomics and Whole-Genome Sequencing to Detect Antibiotic Resistance Genes in Bacterial Strains Co-Occurring Simultaneously in a Brazilian Hospital.Antibiotics (Basel, Switzerland) · 2021Article
- Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation.Frontiers in microbiology · 2021Article
- A novel incompatibility group X3 plasmid carryingRNA biology · 2020Article
- Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance inInternational journal of molecular sciences · 2020Review
- Carbapenemases: TransformingBiomolecules · 2020Review
- Spreading Patterns of NDM-ProducingAntimicrobial agents and chemotherapy · 2019Article
- Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST258 isolated from a Japanese patient without a history of foreign travel - a new public health concern in Japan: a case report.BMC infectious diseases · 2019Article
- Epidemic IncX3 plasmids spreading carbapenemase genes in the United Arab Emirates and worldwide.Infection and drug resistance · 2019Article
- Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae.Microbial genomics · 2018Review
- Genomic and functional characterisation of IncX3 plasmids encoding blaScientific reports · 2018Article
- Circulation ofAntimicrobial agents and chemotherapy · 2017Article
- Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.Scientific reports · 2017Article
- Insights into a NovelFrontiers in microbiology · 2017Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IncX family of plasmids has recently been expanded to include at least four subtypes, IncX1-IncX4. The revised classification provides an opportunity for improving our understanding of the sequence diversity of the IncX plasmids and the resistance genes they carried. We described the complete nucleotide sequence of a novel IncX3 plasmid, pKPC-NY79 (42,447 bp) from a sequence-type 258 Klebsiella pneumoniae strain that was isolated from a patient who was hospitalized in New York, United States. In pKPC-NY79, the plasmid scaffold and genetic load region were highly similar to homologous regions in pIncX-SHV (IncX3, JN247852) and the bla KPC carrying pKpQIL (IncFIIk, GU595196), respectively, indicating that it has possibly arisen through recombination of plasmids. The bla KPC-2 gene, as part of a transposon Tn4401a, was found within the genetic load region. The backbone of pKPC-NY79 differs from pIncX-SHV by a deletion involving the gene tandem hns-topB (encoding H-NS protein and topoisomerase III, respectively) and a putative ATPase gene. Unexpectedly, the impact of the hns-topB deletion on host fitness and plasmid stability was found to be small. In conclusion, the findings contribute to a better understanding of the plasmid platforms carrying bla KPC and of variations in the backbone of the IncX3 plasmids.
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