SynthesisThe Cochrane database of systematic reviews2013
Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus.
Synthesis in The Cochrane database of systematic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Ventriculo-peritoneal shunting devices for hydrocephalus.The Cochrane database of systematic reviews · 2020Pooled it
- Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus.The Cochrane database of systematic reviews · 2013Pooled it
- TRPV4 inhibition as a pharmacotherapy for post-hemorrhagic hydrocephalus.Fluids and barriers of the CNS · 2026Article
- Estimation of metabolic water production in human and rat brain and spinal cord.Fluids and barriers of the CNS · 2026Article
- Glucagon-like peptide-1 receptor modulates cerebrospinal fluid secretion and intracranial pressure in rats.Fluids and barriers of the CNS · 2025Article
- The NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Evolution of Ventriculoperitoneal Shunt Valves and Why They Fail.World neurosurgery · 2025Review
- Design of a piezoelectrically actuated hydrocephalus shunt valve.Medical & biological engineering & computing · 2023Article
- Right Transcephalic Ventriculo-Subclavian Shunt in the Surgical Treatment of Hydrocephalus-An Original Procedure for Drainage of Cerebrospinal Fluid into the Venous System.Journal of clinical medicine · 2023Article
- Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure.Fluids and barriers of the CNS · 2022Article
- Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus.Fluids and barriers of the CNS · 2022Article
- Reconsidering Ventriculoperitoneal Shunt Surgery and Postoperative Shunt Valve Pressure Adjustment: Our Approaches Learned From Past Challenges and Failures.Frontiers in neurology · 2021Review
- Cotransporter-mediated water transport underlying cerebrospinal fluid formation.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince 1965 many ventriculo-peritoneal shunt systems have been inserted worldwide to treat hydrocephalus. The most frequent indication in adults is normal pressure hydrocephalus (NPH), a condition that can be difficult to diagnose precisely. Surgical intervention with flow-regulated and differential pressure-regulated ventriculo-peritoneal shunts remains controversial. Knowledge about the benefits and harms of these interventions is limited.
objectivesThe objective of this review is to summarize the evidence on benefits and harms of flow-regulated versus differential pressure-regulated shunt valves for adult patients with NPH, based on reported findings of randomised clinical trials. SEARCH
methodsThe ALOIS (www.medicine.ox.ac.uk/alois), the Cochrane Dementia and Cognitive Improvement Group Specialized Register; MEDLINE (from 1950) (Ovid SP); EMBASE (from 1980) (Ovid SP); CINAHL (from 1980) (EBSCOhost); PsycINFO (from 1806) (Ovid SP); LILACS (from 1982 ) (BIREME); ClinicalTrials.gov; Umin Japan Trial Register; WHO portal;The Cochrane Library's Central Register of Controlled trials (CENTRAL); ISI Web of Knowledge Conference Proceedings; Index to Theses; and Australasian Digital Theses were searched until May 16, 2012.The search terms used were NPH, "normal pressure hydrocephalus," iNPH, idiopathic normal pressure hydrocephalus, sNPH, and "secondary normal pressure hydrocephalus." SELECTION CRITERIA: We planned to include randomised clinical trials comparing flow-regulated versus differential pressure-regulated shunt valves. DATA COLLECTION AND ANALYSIS: Two authors with expert knowledge within the field independently reviewed studies for eligibility, assessed risk of bias, and extracted data. MAIN
resultsNo randomised clinical trials comparing flow-regulated versus differential pressure-regulated shunt valves were found. AUTHORS'
conclusionsThere is no evidence from randomised clinical trials indicates that flow-regulated and differential pressure-regulated shunt valves differ with regard to clinical outcome, shunt failure, or intervention risks. Randomised clinical trials are needed that take into account the large number of VP shunts implanted each year in patients with NPH.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.