ArticleMicrobiology (Reading, England)2013
Potassium transport of Salmonella is important for type III secretion and pathogenesis.
Article in Microbiology (Reading, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Article
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- Regulation of potassium uptake inJournal of bacteriology · 2024Article
- c-di-AMP determines the hierarchical organization of bacterial RCK proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effect of glutathione-transport-related geneApplied and environmental microbiology · 2024Article
- For Someone, You Are the Whole World: Host-Specificity ofInternational journal of molecular sciences · 2023Article
- The clinical features and genomic epidemiology of carbapenem-resistant Acinetobacter baumannii infections at a tertiary hospital in Vietnam.Journal of global antimicrobial resistance · 2023Article
- Transcriptome sequencing reveals the difference in the expression of biofilm and planktonic cells between two strains ofBiofilm · 2022Article
- Microbiological Safety and Shelf-Life of Low-Salt Meat Products-A Review.Foods (Basel, Switzerland) · 2022Review
- The PTSmBio · 2022Article
- TrkA serves as a virulence modulator inFrontiers in cellular and infection microbiology · 2022Article
- Alteribacter salitolerans sp. nov., isolated from a saline-alkaline soil.Archives of microbiology · 2021Article
- Molecular Mechanisms for Bacterial Potassium Homeostasis.Journal of molecular biology · 2021Review
- Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections.Infection and immunity · 2021Review
- Abundant Monovalent Ions as Environmental Signposts for Pathogens during Host Colonization.Infection and immunity · 2021Review
- Role of theFrontiers in genetics · 2021Article
- Comprehensive Single Cell Analyses of the Nutritional Environment of IntracellularFrontiers in cellular and infection microbiology · 2021Article
- Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel.Frontiers in microbiology · 2021Article
- Genetic Variants and Phenotypic Characteristics ofMicroorganisms · 2020Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Intracellular cations are essential for the physiology of all living organisms including bacteria. Cations such as potassium ion (K(+)), sodium ion (Na(+)) and proton (H(+)) are involved in nearly all aspects of bacterial growth and survival. K(+) is the most abundant cation and its homeostasis in Escherichia coli and Salmonella is regulated by three major K(+) transporters: high affinity transporter Kdp and low affinity transporters Kup and Trk. Previous studies have demonstrated the roles of cations and cation transport in the physiology of Escherichia coli; their roles in the virulence and physiology of pathogenic bacteria are not well characterized. We have previously reported that the Salmonella K(+) transporter Trk is important for the secretion of effector proteins of the type III secretion system (TTSS) of Salmonella pathogenicity island 1 (SPI-1). Here we further explore the role of Salmonella cation transport in virulence in vitro and pathogenesis in animal models. Impairment of K(+) transport through deletion of K(+) transporters or exposure to the chemical modulators of cation transport, gramicidin and valinomycin, results in a severe defect in the TTSS of SPI-1, and this defect in the TTSS was not due to a failure to regulate intrabacterial pH or ATP. Our results also show that K(+) transporters are critical to the pathogenesis of Salmonella in mice and chicks and are involved in multiple growth and virulence characteristics in vitro, including protein secretion, motility and invasion of epithelial cells. These results suggest that cation transport of the pathogenic bacterium Salmonella, especially K(+) transport, contributes to its virulence in addition to previously characterized roles in maintaining homeostasis of bacteria.
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