ArticleAsian journal of andrology2013
The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice.
Article in Asian journal of andrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- MicroRNAs as diagnostic biomarkers in diabetes male infertility: a systematic review.Molecular biology reports · 2024Pooled it
- Novel reference range values for serum testosterone: a cross-sectional study of 200,000 males.Journal of endocrinological investigation · 2024Article
- Korean Ginseng Berry Extract Enhances the Male Steroidogenesis EnzymesThe world journal of men's health · 2023Article
- New Insight into Molecular and Hormonal Connection in Andrology.International journal of molecular sciences · 2021Review
- Questioning the evidence behind the Saturation Model for testosterone replacement therapy in prostate cancer.Investigative and clinical urology · 2020Review
- MicroRNA-205 is associated with diabetes mellitus-induced erectile dysfunction via down-regulating the androgen receptor.Journal of cellular and molecular medicine · 2019Article
- Correlation between insulin-induced estrogen receptor methylation and atherosclerosis.Cardiovascular diabetology · 2016Article
- The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia.Osteoporosis and sarcopenia · 2016Review
- Translational Perspective on the Role of Testosterone in Sexual Function and Dysfunction.The journal of sexual medicine · 2016Review
- Androgen receptor DNA methylation regulates the timing and androgen sensitivity of mouse prostate ductal development.Developmental biology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population studies have suggested an association between diabetes and the symptoms of testosterone deficiency. Recently, the expression of the androgen receptor (AR) has been shown to be decreased in diabetic patients. Furthermore, diabetes has been shown to induce global methylation. In this study, we used an animal model to investigate whether diabetes results in increased methylation of the AR promoter and whether these changes are associated with the decreased expression of AR in penile cavernosal smooth muscle tissue. Twenty C57BL/6J mice were divided into two groups, receiving either high- (mature diabetic) or low- (mature control) caloric meals for 14 weeks. Another 10 mice were killed at 1 week (young control). Animals in the mature diabetic group showed decreased testosterone levels, although this was not statistically significant. In both control groups, no significant methylation was observed in the AR promoter region CpG island (-85 to +339). In the mature diabetic group, significant methylation was observed at +185 and +200 of the AR promoter. These changes were associated with increased homeostatic model assessment for insulin resistance (HOMA-IR) and decreased corpus cavernosal tissue mass and expression of AR mRNA and protein. We conclude that in these animals, insulin resistance increased the methylation of the GC-rich regions of the AR promoter, leading to decreased AR expression.
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