Evidence map›Paper›PMID 23728460›Full record

ReviewNature cell biology2013

Control of metastatic progression by microRNA regulatory networks.

Nora Pencheva, Sohail F Tavazoie

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 2 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 2 syntheses or guidelines pooled it, 297 citations in OpenAlex.

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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nora PenchevaLaboratory of Systems Cancer Biology, Rockefeller University, New York, New York 10065, USA.
Sohail F Tavazoie
Rockefeller University · US

Funding

Transforming Translational Science and Education to Benefit Human HealthKL2RR024142 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2006 to 2011
$4.5M
The discovery of microRNAs that predict chemotherapeutic responsiveness of cancerDP2OD006506 · OD · ROCKEFELLER UNIVERSITY · PI TAVAZOIE, SOHAIL F. · 2009 to 2009
$2.5M
NCRR NIH HHS KL2 RR024142NIH HHS DP2 OD006506
6 · The paper itself

Abstract

Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autonomous cancer phenotypes, whereas others modulate the cell-extrinsic composition of the metastatic microenvironment. The use of small RNAs as probes into the molecular and cellular underpinnings of metastasis holds promise for the identification of candidate genes for potential therapeutic intervention.

Indexed as

AnimalsDisease ProgressionGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasm MetastasisNeoplasmsRegulatory Sequences, Ribonucleic AcidSignal TransductionMicroRNAsRegulatory Sequences, Ribonucleic Acid

Identifiers

PMID23728460
PMCPMC4678324
OpenAlexW2042865509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.