SynthesisInteractive cardiovascular and thoracic surgery2013
Bicuspid aortic valve aortopathy: genetics, pathophysiology and medical therapy.
Synthesis in Interactive cardiovascular and thoracic surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction: A meta-analysis.Clinical cardiology · 2021Pooled it
- A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?Oxidative medicine and cellular longevity · 2018Trial
- Trends in Bicuspid Aortic Valve-Attributable Death in the United States From 2010 to 2020.Journal of the American Heart Association · 2025Article
- Navigating the challenges of bicuspid aortic valve-aortopathy.Global cardiology science & practice · 2023Review
- Bicuspid aortic valve with associated aortopathy, significant left ventricular hypertrophy or concomitant hypertrophic cardiomyopathy: A diagnostic and therapeutic challenge.World journal of clinical cases · 2023Review
- Aortopathies: From Etiology to the Role of Arterial Stiffness.Journal of clinical medicine · 2023Review
- A Segmental Approach from Molecular Profiling to Medical Imaging to Study Bicuspid Aortic Valve Aortopathy.Cells · 2022Article
- Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease.Cellular and molecular neurobiology · 2022Review
- Point on the Aortic Bicuspid Valve.Life (Basel, Switzerland) · 2022Review
- Two MicroRNAs, miR-34a and miR-125a, Are Implicated in Bicuspid Aortopathy by Modulating Metalloproteinase 2.Biochemical genetics · 2022Article
- Clinical implications of the biomechanics of bicuspid aortic valve and bicuspid aortopathy.Frontiers in cardiovascular medicine · 2022Review
- Surgical management of the aortic arch in patients with inherited aortopathy.Frontiers in cardiovascular medicine · 2022Review
- Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.Frontiers in cardiovascular medicine · 2022Article
- Medial tunica degeneration of the ascending aortic wall is associated with specific microRNA changes in bicuspid aortic valve disease.Molecular medicine reports · 2021Article
- Causal Relationship of the Transverse Left Ventricular Band and Bicuspid Aortic Valve.Sultan Qaboos University medical journal · 2021Article
- Should all patients with aortic aneurysm and bicuspid aortic valve also undergo hemiarch?JTCVS open · 2021Article
- Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system.Scientific reports · 2021Article
- [Gene mutation analysis of 19 Uighur families with aortic disease in Kashgar, China].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome.Scientific reports · 2019Article
- Bicuspid aortic valve related aortopathy.General thoracic and cardiovascular surgery · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between ascending aortic aneurysm (AA) and bicuspid aortic valve (BAV) has been well established. Different genetic, haemodynamic and cardiovascular risk factors have been implicated in the development and progression of AA. However, to date, definite conclusions cannot be drawn regarding the exact molecular, cellular and haemodynamic mechanisms causing BAV-associated aortopathy. For this study, we performed a thorough electronic systematic review of the literature using MEDLINE (1960-2012) and EMBASE databases. MeSH terms included: 'bicuspid aortic valve and ascending aorta', 'bicommissural aortic valve and aneurysm', 'bicuspid aortopathy', 'bicuspid aortic valve pathophysiology', 'bicuspid aortic valve and genetics' and 'bicuspid aortic valve and treatment'. We aim in this review to discuss the mechanisms, pathophysiology, genetics and modern drug therapy in the context of BAV-associated aortopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.