ArticleNeuroradiology2013
Dynamic evaluation of stasis filling phenomenon with computed tomography in diagnosis of brain death.
Article in Neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Computed tomography angiography in the diagnosis of brain death: a systematic review and meta-analysis.Neurocritical care · 2014Pooled it
- Death by neurologic criteria: a nuclear medicine approach based on the 2023 AAN/AAP/CNS/SCCM Guideline and 2025 SNMMI Procedure Standard.Pediatric radiology · 2026Review
- Review
- Role of Clinical and Multimodality Neuroimaging in the Evaluation of Brain Death/Death by Neurologic Criteria and Recent Highlights from 2023 Updated Guidelines.Diagnostics (Basel, Switzerland) · 2024Review
- Computed tomography angiography in the diagnosis of brain death: Implementation and results in Germany.European journal of neurology · 2024Article
- Measuring brain perfusion by CT or MR as ancillary tests for diagnosis of brain death: a systematic review and meta-analysis.BJR open · 2024Article
- Ancillary testing for neurologic determination of death in adults: in search of a surrogate of clinical function.Intensive care medicine · 2023Article
- Encephalo-Arterio-Synangiosis with Cranioplasty after Treatment of Acute Subdural Hematoma Associated with Subcortical Hemorrhage Due to Unilateral Moyamoya Disease.Case reports in neurological medicine · 2023Article
- Cerebral blood vessels and perfusion in the pediatric brain death: five cases studied by neuroimaging.Neuroradiology · 2022Article
- Brain death: a clinical overview.Journal of intensive care · 2022Review
- Implementation of Computed Tomography Angiography (CTA) and Computed Tomography Perfusion (CTP) in Polish Guidelines for Determination of Cerebral Circulatory Arrest (CCA) during Brain Death/Death by Neurological Criteria (BD/DNC) Diagnosis Procedure.Journal of clinical medicine · 2021Article
- Computed tomography angiography scoring systems and the role of skull defects in the confirmation of brain death.Scientific reports · 2021Article
- Assessment of Cerebral Circulatory Arrest via CT Angiography and CT Perfusion in Brain Death Confirmation.Korean journal of radiology · 2021Article
- Neurological determination of death in isolated brainstem lesions: A case report to highlight the issues involved.Journal of the Intensive Care Society · 2020Article
- Impact of Skull Defects on the Role of CTA for Brain Death Confirmation.AJNR. American journal of neuroradiology · 2019Observational
- Computed Tomography Perfusion is a Useful Adjunct to Computed Tomography Angiography in the Diagnosis of Brain Death.Clinical neuroradiology · 2019Article
- The Role of Neuroimaging in the Determination of Brain Death.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Accuracy of Computed Tomographic Perfusion in Diagnosis of Brain Death: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- [Angiographic procedures for determination of cessation of cerebral circulation].Der Nervenarzt · 2016Article
- [Not Available].Clinical neuroradiology · 2015Review
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12 authors.
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Abstract
introductionStasis filling, defined as delayed, weak, and persistent opacification of proximal segments of the cerebral arteries, is frequently found in brain dead patients. This phenomenon causes a major problem in the development of reliable computed tomographic angiography (CTA) protocol in the diagnosis of brain death (BD). The aim of our study was to characterize stasis filling in the diagnosis of BD. To achieve this, we performed a dynamic evaluation of contrast enhancement of the cerebral and extracranial arteries in patients with BD and controls.
methodsStudy population included 30 BD patients, who showed stasis filling in computed tomographic perfusion (CTP) series. Thirty patients, after clipping of an intracranial aneurysm, constituted the control group. The study protocol consisted of CTA, CTP, and angiography. Time-density curves (TDCs) of cerebral and extracranial arteries were generated using 40-s series of CTP.
resultsCerebral TDCs in BD patients represented flat curves in contrast to TDCs in controls, which formed steep and narrow Gaussian curves. We found longer time to peak enhancement in BD patients than in controls (32 vs. 21 s; p < 0.0001). In BD patients, peak enhancement in the cerebral arteries occurred with a median delay of 14.5 s to peak in extracranial arteries, while no delay was noted in controls (p < 0.0001). Cerebral arteries in BD patients showed lower peak enhancement than controls (34.5 vs. 81.5 HU; p < 0.0001). In all BD patients, CTP revealed zero values of cerebral blood flow and volume. Angiography showed stasis filling in 14 (46.7 %) and non-filling in 16 (53.3 %) cases.
conclusionA confrontation of stasis filling with CTP results showed that stasis filling is not consistent with preserved cerebral perfusion, thus does not preclude diagnosis of BD.
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