ArticlePhysical chemistry chemical physics : PCCP2013
SFG analysis of surface bound proteins: a route towards structure determination.
Article in Physical chemistry chemical physics : PCCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Specific and non-specific interactions of fibronectin with zwitterionic peptoid brushes studied by molecular dynamics simulation.Physical chemistry chemical physics : PCCP · 2025Article
- Theoretical basis for interpreting heterodyne chirality-selective sum frequency generation spectra of water.The Journal of chemical physics · 2024Article
- A biomimetic approach towards a universal slippery liquid infused surface coating.Beilstein journal of nanotechnology · 2024Article
- Determination of protein conformation and orientation at buried solid/liquid interfaces.Chemical science · 2023Article
- Developments and Ongoing Challenges for Analysis of Surface-Bound Proteins.Annual review of analytical chemistry (Palo Alto, Calif.) · 2021Article
- Studies of Dynamic Binding of Amino Acids to TiOLangmuir : the ACS journal of surfaces and colloids · 2020Article
- Surface analysis tools for characterizing biological materials.Chemical Society reviews · 2020Review
- Vibrational Sum-Frequency Scattering as a Sensitive Approach to Detect Structural Changes in Collagen Fibers Treated with Surfactants.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Surface Analysis: From Single Crystals to Biomaterials.Surface and interface analysis : SIA · 2018Article
- Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions.Angewandte Chemie (International ed. in English) · 2018Review
- Nonlinear Optical Methods for Characterization of Molecular Structure and Surface Chemistry.Topics in catalysis · 2018Article
- Orientation and conformation of osteocalcin adsorbed onto calcium phosphate and silica surfaces.Biointerphases · 2017Article
- Interplay between adsorbed peptide structure, trapped water, and surface hydrophobicity.Biointerphases · 2017Article
- Predicting the orientation of protein G B1 on hydrophobic surfaces using Monte Carlo simulations.Biointerphases · 2016Article
- Differential surface activation of the A1 domain of von Willebrand factor.Biointerphases · 2016Article
- In Situ Investigation of Peptide-Lipid Interaction Between PAP248-286 and Model Cell Membranes.The Journal of membrane biology · 2016Article
- Probing Site-Specific Structural Information of Peptides at Model Membrane Interface In Situ.Journal of the American Chemical Society · 2015Article
- Experimental characterization of adsorbed protein orientation, conformation, and bioactivity.Biointerphases · 2015Article
- Unveiling the membrane-binding properties of N-terminal and C-terminal regions of G protein-coupled receptor kinase 5 by combined optical spectroscopies.Langmuir : the ACS journal of surfaces and colloids · 2014Article
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2 authors.
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Abstract
The surface of a material is rapidly covered with proteins once that material is placed in a biological environment. The structure and function of these bound proteins play a key role in the interactions and communications of the material with the biological environment. Thus, it is crucial to gain a molecular level understanding of surface bound protein structure. While X-ray diffraction and solution phase NMR methods are well established for determining the structure of proteins in the crystalline or solution phase, there is not a corresponding single technique that can provide the same level of structural detail about proteins at surfaces or interfaces. However, recent advances in sum frequency generation (SFG) vibrational spectroscopy have significantly increased our ability to obtain structural information about surface bound proteins and peptides. A multi-technique approach of combining SFG with (1) protein engineering methods to selectively introduce mutations and isotopic labels, (2) other experimental methods such as time-of-flight secondary ion mass spectrometry (ToF-SIMS) and near edge X-ray absorption fine structure (NEXAFS) to provide complementary information, and (3) molecular dynamic (MD) simulations to extend the molecular level experimental results is a particularly promising route for structural characterization of surface bound proteins and peptides. By using model peptides and small proteins with well-defined structures, methods have been developed to determine the orientation of both backbone and side chains to the surface.
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