ReviewInternational journal of molecular sciences2013
An overview of biological macromolecule crystallization.
Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- High-resolution structure of monomeric photosystem I from Thermosynechococcus vestitus.Photosynthesis research · 2026Article
- Bioengineered Silver Nanoparticles: Next-Generation Biogenic Synthesis Strategies for Precision Biomedical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Advances of 3D microcrystals electron diffraction for transmembrane protein structure determination.Biophysical journal · 2026Review
- Shoebill: an interpretable AlphaFold2-informed predictor of protein crystallization propensity using XGBoost.Briefings in bioinformatics · 2026Article
- Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals.Nature communications · 2026Article
- Biomolecular Crystallisation Through Soft Templates and Seeding.Advances in biochemical engineering/biotechnology · 2026Review
- Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals.Acta crystallographica. Section D, Structural biology · 2026Article
- Quality assurance of functional food products using physical field-assisted freezing.Frontiers in nutrition · 2026Review
- Theoretical Perspectives for Biomolecular Crystallization Prediction.Advances in biochemical engineering/biotechnology · 2026Review
- The Crystallography of Enzymes: A Retrospective and Beyond.Crystals · 2025Article
- Detergent Choice Shapes the Solution Structures of Photosystems I and II: Implications for Crystallization and High-Resolution Studies.The journal of physical chemistry. B · 2025Article
- An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics.Crystal growth & design · 2025Article
- Review
- Exploring the coordination chemistry of ruthenium complexes with lysozymes: structural and in-solution studies.Frontiers in chemistry · 2024Article
- Inside outACS sustainable chemistry & engineering · 2023Article
- Complex Formation between CytochromeInternational journal of molecular sciences · 2022Article
- Identification, structure determination and analysis of Mycobacterium smegmatis acyl-carrier protein synthase (AcpS) crystallized serendipitously.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Bacterial Transcriptional Regulators: A Road Map for Functional, Structural, and Biophysical Characterization.International journal of molecular sciences · 2022Review
- Protein Crystallization of Two Recombinant Lpt Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A simple pressure-assisted method for MicroED specimen preparation.Nature communications · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elucidation of the three dimensional structure of biological macromolecules has provided an important contribution to our current understanding of many basic mechanisms involved in life processes. This enormous impact largely results from the ability of X-ray crystallography to provide accurate structural details at atomic resolution that are a prerequisite for a deeper insight on the way in which bio-macromolecules interact with each other to build up supramolecular nano-machines capable of performing specialized biological functions. With the advent of high-energy synchrotron sources and the development of sophisticated software to solve X-ray and neutron crystal structures of large molecules, the crystallization step has become even more the bottleneck of a successful structure determination. This review introduces the general aspects of protein crystallization, summarizes conventional and innovative crystallization methods and focuses on the new strategies utilized to improve the success rate of experiments and increase crystal diffraction quality.
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