ArticleThe EMBO journal2013
The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells.
Article in The EMBO journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- The oncogenic microRNA miR-222 promotes human LINE-1 retrotransposition.RNA biology · 2025Article
- ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network.Nature structural & molecular biology · 2025Article
- Review
- Repeat Element Activation-Driven Inflammation: Role of NFκB and Implications in Normal Development and Cancer?Biomedicines · 2022Review
- Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice.International neurourology journal · 2022Article
- Unique metabolic phenotype and its transition during maturation of juvenile male germ cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Alterations of epigenetic regulators and P53 mutations in murine mesenchymal stem cell cultures: A possible mechanism of spontaneous transformation.Cancer biomarkers : section A of Disease markers · 2021Article
- Polycystic Ovary Syndrome and Risk of Five Common Psychiatric Disorders Among European Women: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas.Cancer cell international · 2020Article
- Article
- Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice.PLoS genetics · 2017Article
- Eya2, a Target Activated by Plzf, Is Critical forMolecular and cellular biology · 2017Article
- Upregulation of PLZF is Associated with Neuronal Injury in Lipopolysaccharide-Induced Neuroinflammation.Neurochemical research · 2016Article
- Multiple layers of transcriptional regulation by PLZF in NKT-cell development.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia.Development (Cambridge, England) · 2016Article
- Restricting retrotransposons: a review.Mobile DNA · 2016Review
- Guardian of the Human Genome: Host Defense Mechanisms against LINE-1 Retrotransposition.Frontiers in chemistry · 2016Review
- Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.Immunity · 2015Article
- Genome-wide methylation analysis in Silver-Russell syndrome patients.Human genetics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Germ cells and adult stem cells maintain tissue homeostasis through a finely tuned program of responses to both physiological and stress-related signals. PLZF (Promyelocytic Leukemia Zinc Finger protein), a member of the POK family of transcription factors, acts as an epigenetic regulator of stem cell maintenance in germ cells and haematopoietic stem cells. We identified L1 retrotransposons as the primary targets of PLZF. PLZF-mediated DNA methylation induces silencing of the full-length L1 gene and inhibits L1 retrotransposition. Furthermore, PLZF causes the formation of barrier-type boundaries by acting on inserted truncated L1 sequences in protein coding genes. Cell stress releases PLZF-mediated repression, resulting in L1 activation/retrotransposition and impaired spermatogenesis and myelopoiesis. These results reveal a novel mechanism of action by which, PLZF represses retrotransposons, safeguarding normal progenitor homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.