ArticleNature neuroscience2013
Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 191 citations in OpenAlex.
- Advancing insights into the neuroendocrine basis of socio-sexual interactions in mammals.Endocrinology · 2026Review
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.Journal of neuroendocrinology · 2026Article
- Adolescent social instability stress alters social processes in male prairie voles.Frontiers in behavioral neuroscience · 2026Article
- Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens.Scientific reports · 2025Article
- PVN-NAc Shell-VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Pair bond quality influences social conditioned place preference expression, passive coping behavior, and central oxytocin receptor expression following partner loss in male prairie voles.Social neuroscience · 2024Article
- Epigenetic aging studies of pair bonding in prairie voles.Scientific reports · 2024Article
- Transcriptomic changes in the posterior pallium of male zebra finches associated with social niche conformance.BMC genomics · 2024Article
- Re-wiring of the bonded brain: Gene expression among pair bonded female prairie voles changes as they transition to motherhood.Genes, brain, and behavior · 2024Article
- Transcriptomic signatures associated with underlying rapid changes in the early phase brain of bi-directional sex change inRoyal Society open science · 2023Article
- A test of the social behavior network reveals differential patterns of neural responses to social novelty in bonded, but not non-bonded, male prairie voles.Hormones and behavior · 2023Article
- Motherhood and DREADD manipulation of the nucleus accumbens weaken established pair bonds in female prairie voles.Hormones and behavior · 2023Article
- Article
- Transcriptomic analysis of paternal behaviors in prairie voles.BMC genomics · 2022Article
- Sex-specific and social experience-dependent oxytocin-endocannabinoid interactions in the nucleus accumbens: implications for social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward.International journal of molecular sciences · 2022Review
- Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles.Current biology : CB · 2022Article
- Reciprocal processes of sensory perception and social bonding: an integrated social-sensory framework of social behavior.Genes, brain, and behavior · 2022Review
3 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
In the socially monogamous prairie vole (Microtus ochrogaster), mating induces enduring pair-bonds that are initiated by partner preference formation and regulated by a variety of neurotransmitters, including oxytocin, vasopressin and dopamine. We examined potential epigenetic mechanisms mediating pair-bond regulation and found that the histone deacetylase inhibitors sodium butyrate and trichostatin A (TSA) facilitated partner preference formation in female prairie voles in the absence of mating. This was associated with a specific upregulation of oxytocin receptor (OTR, oxtr) and vasopressin V1a receptor (V1aR, avpr1a) in the nucleus accumbens (NAcc), through an increase in histone acetylation at their respective promoters. Furthermore, TSA-facilitated partner preference was prevented by OTR or V1aR blockade in the NAcc. Notably, mating-induced partner preference triggered the same epigenetic regulation of oxtr and avpr1a gene promoters as TSA. These observations indicate that TSA and mating facilitate partner preference through epigenetic events, providing, to the best of our knowledge, the first direct evidence for epigenetic regulation of pair-bonding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.