ArticleScientific reports2013
Metabolic scaling in solid tumours.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- 3D melanoma spheroid model for the development of positronium biomarkers.Scientific reports · 2023Article
- Universal scaling laws rule explosive growth in human cancers.Nature physics · 2020Article
- The control of acidity in tumor cells: a biophysical model.Scientific reports · 2020Article
- Modeling of the metabolic energy dissipation for restricted tumor growth.Journal of bioenergetics and biomembranes · 2017Article
- Allometric scaling in-vitro.Scientific reports · 2017Article
- Pulsation-limited oxygen diffusion in the tumour microenvironment.Scientific reports · 2017Article
- The proportion of genes in a functional category is linked to mass-specific metabolic rate and lifespan.Scientific reports · 2015Article
- Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis.Expert review of molecular diagnostics · 2013Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. Recently, by combining the diffusion of oxygen, nutrients, and metabolites in the extracellular environment, and the internal motions that mix live and dead cells, we derived a growth law of solid tumours which is linked to parameters at the cellular level. Here we use this growth law to obtain a metabolic scaling law for solid tumours, which is obeyed by tumours of different histotypes both in vitro and in vivo, and we display its relation with the fractal dimension of the distribution of live cells in the tumour mass. The scaling behaviour is related to measurable parameters, with potential applications in the clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.