ArticleTrends in genetics : TIG2013
On the definition and measurement of pleiotropy.
Article in Trends in genetics : TIG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Patterns and evolutionary consequences of pleiotropy.Annual review of ecology, evolution, and systematics · 2023Article
- Trade-off between local replication and long-distance dissemination during experimental evolution of a satellite RNA.Frontiers in microbiology · 2023Article
- Network Topology Can Explain Differences in Pleiotropy Between Cis- and Trans-regulatory Mutations.Molecular biology and evolution · 2022Article
- Pleiotropic effects of trans-regulatory mutations on fitness and gene expression.Science (New York, N.Y.) · 2022Article
- Total genetic contribution assessment across the human genome.Nature communications · 2021Article
- Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.PLoS biology · 2020Article
- Multiple Forms of Multifunctional Proteins in Health and Disease.Frontiers in cell and developmental biology · 2020Review
- Alleles of a gene differ in pleiotropy, often mediated through currency metabolite production, in E. coli and yeast metabolic simulations.Scientific reports · 2018Article
- Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.Annals of the New York Academy of Sciences · 2017Review
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- Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?Proceedings. Biological sciences · 2015Article
- The differential view of genotype-phenotype relationships.Frontiers in genetics · 2015Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.