ArticleAnnals of epidemiology2013
Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States.
Article in Annals of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Fiber-based vegetarian score and the risk of incident dementia among elderly Chinese adults: a prospective cohort study.Frontiers in nutrition · 2026Article
- The relationship between folic acid and colorectal cancer; a literature review.Annals of medicine and surgery (2012) · 2022Review
- Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer.World journal of gastroenterology · 2020Review
- Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male rats.PloS one · 2020Article
- Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study.American journal of epidemiology · 2019Article
- Key Findings on Alcohol Consumption and a Variety of Health Outcomes From the Nurses' Health Study.American journal of public health · 2016Review
- Alcoholic Beverage Consumption and Chronic Diseases.International journal of environmental research and public health · 2016Review
- Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational study.International journal of cancer · 2015Observational
- Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.The American journal of clinical nutrition · 2014Article
- A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.Nutrients · 2013Observational
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the influence of alcohol consumption on the risk of colorectal cancer according to folic acid fortification period in the United States.
methodsWe evaluated the association between alcohol consumption and colorectal cancer by fortification period (before 1998 vs. after 1998) in 2 prospective cohort studies, the Nurses' Health Study (NHS) of women and the Health Professionals Follow-up Study (HPFS) of men, in which 2793 cases of invasive colorectal cancer were documented.
resultsAlcohol consumption was associated with an increased risk of colorectal cancer. Among nonusers of multivitamins and/or folic acid supplements, the pooled multivariate relative risk for ≥30 g/d drinkers versus nondrinkers was 1.36 (95% confidence interval [95% CI], 1.09-1.70; P for trend, 0.02). The effect of alcohol consumption was slightly stronger in the prefolic acid fortification period (1980 NHS/1986 HPFS-1998) than in the postfortification period (1998-2008); the pooled multivariate relative risks for ≥30 g/d drinkers versus nondrinkers were 1.31 (95% CI, 1.00-1.71; P for trend, 0.10) in the prefortification period and 1.07 (95% CI, 0.69-1.65; P for trend, 0.67) in the postfortification period.
conclusionsFolic acid fortification may attenuate the adverse effect of high alcohol consumption on the risk of colorectal cancer.
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Registered trials
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