Evidence map›Paper›PMID 23726803›Full record

ArticleClinical biochemistry2013

Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure.

John J Gildea, Julia M Carlson, Cynthia D Schoeffel, Robert M Carey, Robin A Felder

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Clinical biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Urinary miRNAs: Technical Updates.MicroRNA (Shariqah, United Arab Emirates) · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Extracellular vesicles in vascular remodeling.Acta pharmacologica Sinica · 2022
    Review
  13. Article
  14. From salt to hypertension, what is missed?Journal of clinical hypertension (Greenwich, Conn.) · 2021
    Review
  15. Importance of extracellular vesicles in hypertension.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John J GildeaDepartment of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.
Julia M CarlsonDepartment of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.
Cynthia D SchoeffelDepartment of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Internal Medicine, The University of Virginia Health System, Charlottesville, VA 22908, USA.
Robert M CareyDepartment of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Internal Medicine, The University of Virginia Health System, Charlottesville, VA 22908, USA.
Robin A FelderDepartment of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: raf7k@virginia.edu.
University of Virginia Health System · US

Funding

Spatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAREY, ROBERT MUNSON · 2004 to 2020
$31.8M
RENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4M
NHLBI NIH HHS HL074940NHLBI NIH HHS P01 HL074940NIDDK NIH HHS DK39308
6 · The paper itself

Abstract

objectivesTo investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake. DESIGN AND

methodsHuman urinary exosomal miRNome was examined by microarray.

resultsOf 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity.

conclusionThe expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.

Indexed as

Gene Expression ProfilingBlood PressureExosomesHumansMicroRNAsSodium Chloride, DietaryMicroRNAsSodium Chloride, Dietaryblood pressureBlood pressureBPExosomeinverse salt-sensitiveISSMAPmean arterial pressuremiRNAsalt-resistantSalt-resistantsalt-sensitiveSalt-sensitiveSRSS

Identifiers

PMID23726803
PMCPMC3786136
OpenAlexW2024044199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.