ArticleBiological psychiatry2014
MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 92 citations in OpenAlex.
- Improved approaches to genotyping MAOA-uVNTR polymorphisms with novel allele discovery.Scientific reports · 2025Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Monoamine Oxidase A is a Major Mediator of Mitochondrial Homeostasis and Glycolysis in Gastric Cancer Progression.Cancer management and research · 2020Article
- Gene-environment interactions in antisocial behavior are mediated by early-life 5-HTNeuropharmacology · 2019Article
- Interpreting Behavior Genetic Models: Seven Developmental Processes to Understand.Behavior genetics · 2019Article
- MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli.Scientific reports · 2019Article
- Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update.Current psychiatry reports · 2018Review
- Informed Consent in Translational Genomics: Insufficient Without Trustworthy Governance.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2018Article
- A Genomically Informed Education System? Challenges for Behavioral Genetics.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2018Article
- Gene-Gene-Environment Interactions of Serotonin Transporter, Monoamine Oxidase A and Childhood Maltreatment Predict Aggressive Behavior in Chinese Adolescents.Frontiers in behavioral neuroscience · 2017Article
- Monoamine Oxidase A in Antisocial Personality Disorder and Borderline Personality Disorder.Current behavioral neuroscience reports · 2017Review
- Psychiatric Genetics in Child Custody Proceedings: Ethical, Legal, and Social Issues.Current genetic medicine reports · 2016Article
- Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- The role of monoamine oxidase A in aggression: Current translational developments and future challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- MAOA expression predicts vulnerability for alcohol use.Molecular psychiatry · 2016Article
- MAOA Influences the Trajectory of Attentional Development.Frontiers in human neuroscience · 2016Article
- Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation.Translational psychiatry · 2015Article
- Genetic background of extreme violent behavior.Molecular psychiatry · 2015Article
- Effects of Behavioral Genetic Evidence on Perceptions of Criminal Responsibility and Appropriate Punishment.Psychology, public policy, and law : an official law review of the University of Arizona College of Law and the University of Miami School of Law · 2015Article
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12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMaltreatment by an adult or caregiver during childhood is a prevalent and important predictor of antisocial behaviors in adulthood. A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationship between childhood maltreatment and antisocial behaviors. Although there have been numerous attempts at replicating this observation, results remain inconclusive.
methodsWe examined this gene-environment interaction hypothesis in a sample of 3356 white and 960 black men (aged 24-34) participating in the National Longitudinal Study of Adolescent Health.
resultsPrimary analysis indicated that childhood maltreatment was a significant risk factor for later behaviors that violate rules and the rights of others (p < .05), there were no main effects of MAOA genotype, and MAOA genotype was not a significant moderator of the relationship between maltreatment and antisocial behaviors in our white sample. Post hoc analyses identified a similar pattern of results among our black sample in which maltreatment was not a significant predictor of antisocial behavior. Post hoc analyses also revealed a main effect of MAOA genotype on having a disposition toward violence in both samples and for violent convictions among our black sample. None of these post hoc findings, however, survived correction for multiple testing (p > .05). Power analyses indicated that these results were not due to insufficient statistical power.
conclusionsWe could not confirm the hypothesis that MAOA genotype moderates the relationship between childhood maltreatment and adult antisocial behaviors.
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