ArticleBiological psychiatry2013
Prenatal stress induces increased striatal dopamine transporter binding in adult nonhuman primates.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Prenatal Stress and Prenatal Alcohol Alter the Adult Dopamine System and Alcohol Consumption: Dopamine Drives Drinking Behavior in a Prospective 20-Year Longitudinal Experiment with Rhesus Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways.Journal of psychiatric research · 2025Article
- Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice.bioRxiv : the preprint server for biology · 2024Article
- Novel Dopamine Transporter Inhibitor, CE-123, Ameliorates Spatial Memory Deficits Induced by Maternal Separation in Adolescent Rats: Impact of Sex.International journal of molecular sciences · 2022Article
- Editorial: Sensory Processing Across the Lifespan: A 25-Year Initiative to Understand Neurophysiology, Behaviors, and Treatment Effectiveness for Sensory Processing.Frontiers in integrative neuroscience · 2021Article
- Prenatal Stress Leads to the Altered Maturation of Corticostriatal Synaptic Plasticity and Related Behavioral Impairments Through Epigenetic Modifications of Dopamine D2 Receptor in Mice.Molecular neurobiology · 2021Article
- Rhesus Macaque Brain Atlas Regions Aligned to an MRI Template.Neuroinformatics · 2019Article
- Chronic stress increases susceptibility to food addiction by increasing the levels of DR2 and MOR in the nucleus accumbens.Neuropsychiatric disease and treatment · 2019Article
- PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder.Frontiers in integrative neuroscience · 2019Article
- Sensory Processing in Rhesus Monkeys: Developmental Continuity, Prenatal Treatment, and Genetic Influences.Child development · 2017Article
- Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder.Neurotoxicity research · 2017Review
- Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition.Neuroscience research · 2016Review
- Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.Psychological bulletin · 2015Review
- Maternal immune activation in nonhuman primates alters social attention in juvenile offspring.Biological psychiatry · 2015Article
- Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters.Frontiers in behavioral neuroscience · 2015Article
- Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.Alcoholism, clinical and experimental research · 2014Article
- Dopamine transporter gene susceptibility to methylation is associated with impulsivity in nonhuman primates.Journal of neurophysiology · 2014Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo determine the effects in adult offspring of maternal exposure to stress and alcohol during pregnancy, we imaged striatal and midbrain dopamine transporter (DAT) binding by positron emission tomography in rhesus monkeys (Macaca mulatta). We also evaluated the relationship between DAT binding and behavioral responses previously found to relate to dopamine D2 receptor density (responsivity to tactile stimuli, performance on a learning task, and behavior during a learning task).
methodsSubjects were adult offspring derived from a 2 × 2 experiment in which pregnant monkeys were randomly assigned to control, daily mild stress exposure (acoustic startle), voluntary consumption of moderate-level alcohol, or both daily stress and alcohol. Adult offspring (n = 38) were imaged by positron emission tomography with the DAT ligand [(18)F]2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane ([(18)F]FECNT).
resultsResults showed that prenatal stress yielded an overall increase of 15% in [(18)F]FECNT binding in the striatum (p = .016), 17% greater binding in the putamen (p = .012), and 13% greater binding in the head of the caudate (p = .028) relative to animals not exposed to prenatal stress. Striatal [(18)F]FECNT binding correlated negatively with habituation to repeated tactile stimulation and positively with tactile responsivity. There were no significant effects of prenatal alcohol exposure on [(18)F]FECNT binding.
conclusionsMaternal exposure to mild daily stress during pregnancy yielded increases in striatal DAT availability that were apparent in adult offspring and were associated with behavioral characteristics reflecting tactile hyperresponsivity, a condition associated with problem behaviors in children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.