Evidence map›Paper›PMID 23726022›Full record

ReviewCurrent opinion in cell biology2013

Lysosome-related organelles: unusual compartments become mainstream.

Michael S Marks, Harry F G Heijnen, Graça Raposo

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed.

  1. Article
  2. Lysosome-related organelles orchestrate guanine crystal formation in pigment cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Epidermal lamellar bodies, essential organelles for the skin barrier.Frontiers in cell and developmental biology · 2025
    Review
  15. Review
  16. Skin lamellar bodies: a unique set of lysosome-related organelles.Frontiers in cell and developmental biology · 2025
    Article
  17. Biogenesis and homeostasis of mast cell lysosome related secretory granules.Frontiers in cell and developmental biology · 2025
    Review
  18. Review
  19. Masks of Albinism: Clinical Spectrum of Hermansky-Pudlak Syndrome.International journal of molecular sciences · 2024
    Article
  20. Article

89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael S MarksDepartment of Pathology & Laboratory Medicine and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. marksm@mail.med.upenn.edu
Harry F G Heijnen
Graça Raposo

Funding

Hermansky Pudlak Syndrome &melanosome formationR01EY015625 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Michael S Marks · 2004 to 2026
$9.2M
Melanosome BiogenesisR01AR048155 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MARKS, MICHAEL S · 2002 to 2017
$4.2M
Disease-related defects in dendritic cell processing of bacterial antigensR21AI092398 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MARKS, MICHAEL S · 2011 to 2012
$440k
Platelet granule biogenesis in health and diseaseR21HL096865 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MARKS, MICHAEL S · 2010 to 2011
$400k
NEI NIH HHS R01 EY015625NHLBI NIH HHS R21 HL096865NIAID NIH HHS R21 AI092398NIAMS NIH HHS R01 AR048155
6 · The paper itself

Abstract

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.

Indexed as

AnimalsCytoplasmic VesiclesEndocytosisEndosomesHumansLysosomesProtein TransportVertebrates

Identifiers

PMID23726022
PMCPMC3729921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.