Evidence map›Paper›PMID 23725758›Full record

ArticleDevelopmental cell2013

Proteolytic remodeling of the ECM and the geometric control of stem cell fate.

Patricia J Keely

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patricia J KeelyDepartment of Cell and Regenerative Biology and Laboratory for Cell and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. pjkeely@wisc.edu
University of Wisconsin System · US

Funding

Mechanisms Of Cell Migration On 3D Aligned MatricesR01CA142833 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI FRIEDL, ANDREAS, HAHN, KLAUS M. · 2010 to 2020
$3.4M
Biophysical Regulation of Breast DifferentiationR01CA114462 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KEELY, PATRICIA J · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA114462
6 · The paper itself

Abstract

The mechanism by which mechanosignal transduction regulates stem cell fate is not well understood. In this issue of Developmental Cell, Tang et al. (2013) demonstrate that catalytic function of the metalloproteinase MT1-MMP controls ECM structure, cell shape, and an integrin/Rho/YAP-TAZ signaling axis to control osteogenic stem cell fate.

Indexed as

Signal TransductionAcyltransferasesAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsHumansIntegrin beta1Matrix Metalloproteinase 14PhosphoproteinsTranscription FactorsYAP-Signaling ProteinsAcyltransferasesAdaptor Proteins, Signal TransducingCell Cycle ProteinsIntegrin beta1Matrix Metalloproteinase 14Mmp14 protein, mousePhosphoproteinstafazzin protein, mouseTranscription FactorsYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID23725758
OpenAlexW2063935449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.