ArticleBioData mining2013
MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression.
Article in BioData mining, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
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- miRNA expression and interaction with the 3'UTR of FMR1 in FRAXopathy pathogenesis.Non-coding RNA research · 2021Article
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- Plant small RNAs: the essential epigenetic regulators of gene expression for salt-stress responses and tolerance.Plant cell reports · 2018Review
- Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis.Progress in neuro-psychopharmacology & biological psychiatry · 2015Article
- Apparent microRNA-Target-specific Histone Modification in Mammalian Spermatogenesis.Evolutionary bioinformatics online · 2015Article
- Impacts of pretranscriptional DNA methylation, transcriptional transcription factor, and posttranscriptional microRNA regulations on protein evolutionary rate.Genome biology and evolution · 2014Article
- Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction.Methods (San Diego, Calif.) · 2014Article
- Sho-saiko-to, a traditional herbal medicine, regulates gene expression and biological function by way of microRNAs in primary mouse hepatocytes.BMC complementary and alternative medicine · 2014Article
- Biological mechanism analysis of acute renal allograft rejection: integrated of mRNA and microRNA expression profiles.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPublic domain databases nowadays provide multiple layers of genome-wide data e.g., promoter methylation, mRNA expression, and miRNA expression and should enable integrative modeling of the mechanisms of regulation of gene expression. However, researches along this line were not frequently executed.
resultsHere, the public domain dataset of mRNA expression, microRNA (miRNA) expression and promoter methylation patterns in four regions, the frontal cortex, temporal cortex, pons and cerebellum, of human brain were sourced from the National Center for Biotechnology Informations gene expression omnibus, and reanalyzed computationally. A large number of miRNA-mediated regulation of target genes and miRNA-targeting-specific promoter methylation were identified in the six pairwise comparisons among the four brain regions. The miRNA-mediated regulation of target genes was found to be highly correlated with one or both of miRNA-targeting-specific promoter methylation and differential miRNA expression. Genes enriched for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were related to brain function and/or development were found among the target genes of miRNAs whose differential expression patterns were highly correlated with the miRNA-mediated regulation of their target genes.
conclusionsThe combinatorial analysis of miRNA-mediated regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can help reveal the brain region-specific contributions of miRNAs to brain function and development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.