ReviewAnnual review of genomics and human genetics2013
The power of meta-analysis in genome-wide association studies.
Review in Annual review of genomics and human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 17 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 17 syntheses or guidelines pooled it.
- CPNE1: A novel therapeutic target for myopia progression - from genetic GWAS discovery to functional validation in vitro and vivo.Journal of translational medicine · 2026Pooled it
- Genomic dissection of methane emission traits in cattle: A meta-GWAS and heritability analysis across populations.PloS one · 2026Pooled it
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Genome-wide association analysis using multiple Atlantic salmon populations.Genetics, selection, evolution : GSE · 2025Pooled it
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nature genetics · 2024Pooled it
- Reproducible acquisition, management and meta-analysis of nucleotide sequence (meta)data using q2-fondue.Bioinformatics (Oxford, England) · 2022Pooled it
- Robust meta-analysis for large-scale genomic experiments based on an empirical approach.BMC medical research methodology · 2022Pooled it
- Meta-Analysis for Epigenome-Wide Association Studies.Methods in molecular biology (Clifton, N.J.) · 2022Pooled it
- Variance-component-based meta-analysis of gene-environment interactions for rare variants.G3 (Bethesda, Md.) · 2021Pooled it
- Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor.Nature communications · 2019Pooled it
- Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Pooled it
- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Nature communications · 2016Pooled it
- Replication of ZNF804A gene variant associations with risk of heroin addiction.Genes, brain, and behavior · 2015Pooled it
- Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies.Human molecular genetics · 2015Pooled it
- A genome-wide pleiotropy scan for prostate cancer risk.European urology · 2015Pooled it
- The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.Medicine · 2015Pooled it
- Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.Diabetes · 2015Pooled it
- Genome-wide association study of emotional empathy in children.Scientific reports · 2020Trial
- In-silico identification of genetic variants associated with chronic lymphocytic leukemia for diagnostic and therapeutic applications.Scientific reports · 2026Article
- Exploring the Genetic Overlap Between Metabolic Traits and Anorexia Nervosa.Biological psychiatry global open science · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Meta-analysis of multiple genome-wide association (GWA) studies has become common practice over the past few years. The main advantage of this technique is the maximization of power to detect subtle genetic effects for common traits. Moreover, one can use meta-analysis to probe and identify heterogeneity in the effect sizes across the combined studies. In this review, we systematically appraise and evaluate the characteristics of GWA meta-analyses with 10,000 or more subjects published up to June 2012. We provide an overview of the current landscape of variants discovered by GWA meta-analyses, and we discuss and assess with extrapolations from empirical data the value of larger meta-analyses for the discovery of additional genetic associations and new biology in the future. Finally, we discuss some emerging logistical and practical issues related to the conduct of meta-analysis of GWA studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.