ArticleBMC genomics2013
Pan-genome analysis of the emerging foodborne pathogen Cronobacter spp. suggests a species-level bidirectional divergence driven by niche adaptation.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
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- Genomic Analysis ofInternational journal of molecular sciences · 2024Article
- Comparative phylogenomics of Trueperella pyogenes reveals host-based distinction of strains.Antonie van Leeuwenhoek · 2023Article
- Foodborne pathogens in Africa: UnderstandingPublic health challenges · 2023Review
- Characterization ofMicroorganisms · 2022Article
- Comparative Genomic Analysis Reveals Intestinal Habitat Adaptation of Ligilactobacillus equi Rich in Prophage and Degrading CellulaseMolecules (Basel, Switzerland) · 2022Article
- Genome insights from the identification of a novel Pandoraea sputorum isolate and its characteristics.PloS one · 2022Article
- The Secretion of Toxins and Other Exoproteins ofMicroorganisms · 2020Review
- Analysis of the Molecular Diversity AmongFrontiers in microbiology · 2020Article
- Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed byMicroorganisms · 2019Article
- Reconstituting the History of Cronobacter Evolution Driven by Differentiated CRISPR Activity.Applied and environmental microbiology · 2018Article
- Draft genomes ofStandards in genomic sciences · 2018Article
- Genomic characterization of malonate positiveGut pathogens · 2018Article
- Draft Genome Sequence ofGenome announcements · 2017Article
- Profiling of Virulence Determinants in Cronobacter sakazakii Isolates from Different Plant and Environmental Commodities.Current microbiology · 2017Article
- Use of a Pan-Genomic DNA Microarray in Determination of the Phylogenetic Relatedness among Cronobacter spp. and Its Use as a Data Mining Tool to Understand Cronobacter Biology.Microarrays (Basel, Switzerland) · 2017Review
- The driving force of prophages and CRISPR-Cas system in the evolution of Cronobacter sakazakii.Scientific reports · 2017Article
- DNA-Sequence Based Typing of theFrontiers in microbiology · 2017Article
- Multiplexed Lateral Flow Test for Detection and Differentiation ofFrontiers in microbiology · 2017Article
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16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMembers of the genus Cronobacter are causes of rare but severe illness in neonates and preterm infants following the ingestion of contaminated infant formula. Seven species have been described and two of the species genomes were subsequently published. In this study, we performed comparative genomics on eight strains of Cronobacter, including six that we sequenced (representing six of the seven species) and two previously published, closed genomes.
resultsWe identified and characterized the features associated with the core and pan genome of the genus Cronobacter in an attempt to understand the evolution of these bacteria and the genetic content of each species. We identified 84 genomic regions that are present in two or more Cronobacter genomes, along with 45 unique genomic regions. Many potentially horizontally transferred genes, such as lysogenic prophages, were also identified. Most notable among these were several type six secretion system gene clusters, transposons that carried tellurium, copper and/or silver resistance genes, and a novel integrative conjugative element.
conclusionsCronobacter have diverged into two clusters, one consisting of C. dublinensis and C. muytjensii (Cdub-Cmuy) and the other comprised of C. sakazakii, C. malonaticus, C. universalis, and C. turicensis, (Csak-Cmal-Cuni-Ctur) from the most recent common ancestral species. While several genetic determinants for plant-association and human virulence could be found in the core genome of Cronobacter, the four Cdub-Cmuy clade genomes contained several accessory genomic regions important for survival in a plant-associated environmental niche, while the Csak-Cmal-Cuni-Ctur clade genomes harbored numerous virulence-related genetic traits.
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