Evidence map›Paper›PMID 23724162›Full record

ArticleAmerican journal of translational research2013

Novel autoantigens in type 1 diabetes.

Shuhong Han, William Donelan, Hai Wang, Westley Reeves, Li-Jun Yang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. A mutagenesis study of autoantigen optimization for potential T1D vaccine design.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Type 1Micromachines · 2023
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Prevalence of ZnT8 Antibody in Turkish Children and Adolescents with New Onset Type 1 DiabetesJournal of clinical research in pediatric endocrinology · 2018
    Article
  14. Revealing the specificity of regulatory T cells in murine autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  15. Review
  16. Review
  17. Article
  18. Molecular mechanisms in autoimmune type 1 diabetes: a critical review.Clinical reviews in allergy & immunology · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shuhong HanDepartment of Medicine, University of Florida College of Medicine Gainesville, Florida 32610, USA.
William Donelan
Hai Wang
Westley Reeves
Li-Jun Yang
Florida College · US

Funding

Liver to Endocrine Pancreas TransdifferentiationR01DK071831 · NIDDK · UNIVERSITY OF FLORIDA · PI YANG, LIJUN · 2005 to 2009
$1.3M
Insulin-producing cells/in vitro/Adult hepatic stem cellK08DK064054 · NIDDK · UNIVERSITY OF FLORIDA · PI YANG, LIJUN · 2003 to 2007
$617k
NIDDK NIH HHS K08 DK064054NIDDK NIH HHS R01 DK071831
6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM) is characterized by recognition of beta cell proteins as self-antigens, called autoantigens (AAgs), by patients' own CD4+ and CD8+ T cells and/or the products of self-reactive B cells, called autoantibodies. These AAgs are divided into two categories on the basis of beta-cell-specificity. The list of the targets associated with beta cell-specific AAgs is continuously growing. Many T1DM-associated AAgs are well characterized and have important clinical applications for disease prediction, diagnosis, and antigen-specific tolerance immunotherapy. Identification of T1DM-associated AAgs provides insight into the pathogenesis of T1DM and to understanding the clinical aspects of the disease. Since many excellent reviews have covered the previously identified T1DM-associated AAgs exhaustedly, here we only focus on several recently discovered T1DM-AAgs (PDX1, ZnT8, CHGA, and IAAP).

Indexed as

autoantibodiesautoantigenCHGAIAPPimmune toleranceimmunotherapyPdx1Type 1 diabetesZnT8

Identifiers

PMID23724162
PMCPMC3665912
OpenAlexW23894826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.