ArticlePloS one2013
A longitudinal study of hand motor recovery after sub-acute stroke: a study combined FMRI with diffusion tensor imaging.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Neuronal substrates of motor impairment after subcortical ischemic stroke: a functional neuroimaging meta-analysis.Brain structure & function · 2025Pooled it
- Hebbian-Type Primary Motor Cortex Stimulation: A Potential Treatment of Impaired Hand Function in Chronic Stroke Patients.Neurorehabilitation and neural repair · 2020Trial
- Functional versus Nonfunctional Rehabilitation in Chronic Ischemic Stroke: Evidences from a Randomized Functional MRI Study.Neural plasticity · 2016Trial
- Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.Nature communications · 2024Article
- Spontaneous Behavioural Recovery Following Stroke Relates to the Integrity of Parietal and Temporal Regions.Translational stroke research · 2024Article
- Neuroimaging biomarkers of cognitive recovery after ischemic stroke.Frontiers in neurology · 2022Review
- The effect of walnut rolling training on hand function and corticospinal tract.Annals of translational medicine · 2019Article
- Effect of Neuromuscular Electrical Stimulation Training on the Finger Extensor Muscles for the Contralateral Corticospinal Tract in Normal Subjects: A Diffusion Tensor Tractography Study.Frontiers in human neuroscience · 2018Article
- Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke.Translational stroke research · 2017Review
- Regional brain structural abnormality in ischemic stroke patients: a voxel-based morphometry study.Neural regeneration research · 2016Article
- Article
- Change of the Corticospinal Tract in the Unaffected Hemisphere by Change of the Dominant Hand Following Stroke: A Cohort Study.Medicine · 2016Observational
- MRI Biomarkers for Hand-Motor Outcome Prediction and Therapy Monitoring following Stroke.Neural plasticity · 2016Review
- Connectivity measures are robust biomarkers of cortical function and plasticity after stroke.Brain : a journal of neurology · 2015Article
- Specific Correlation between the Hegu Point (LI4) and the Orofacial Part: Evidence from an fMRI Study.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Characterizing relationships of DTI, fMRI, and motor recovery in stroke rehabilitation utilizing brain-computer interface technology.Frontiers in neuroengineering · 2014Article
- Differential activation patterns of FMRI in sleep-deprived brain: restoring effects of acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The influence of functional electrical stimulation on hand motor recovery in stroke patients: a review.Experimental & translational stroke medicine · 2014Review
- Acupuncture Enhances Effective Connectivity between Cerebellum and Primary Sensorimotor Cortex in Patients with Stable Recovery Stroke.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Low-Frequency rTMS and Intensive Occupational Therapy Improve Upper Limb Motor Function and Cortical Reorganization Assessed by Functional Near-Infrared Spectroscopy in a Subacute Stroke Patient.Case reports in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Previous studies have shown that motor recovery of stroke can be assessed by the cortical activity and the structural integrity of the corticospinal tract (CST), but little is known about the relation between the cortical activity and the structural integrity during motor recovery. In the present study, we investigated the changes in brain activities evoked by twenty days' functional electrical stimulation (FES) training in twelve sub-acute stroke patients with unilateral upper-limb disability. We compared cortex activity evoked by wrist movement of eleven stroke patients to that of eleven age-matched healthy subjects to figure out how cortex activity changed after stroke. We also measured the structural integrity represented by the fractional anisotropy (FA) asymmetry of the posterior limb of the internal capsule (PLIC) to find the relationship between the brain activity and the structure integrity. In our study, we found that patients with sub-acute stroke have shown greater activity in the contralesional primary motor cortex (M1) during the affected hand's movement compared with healthy group, while the activity in ipsilesional M1 was decreased after the therapy compared to that before therapy, and the contralesional non-primary motor cortex showed greater activity after therapy. At the baseline we found that the positive correlation between the FA asymmetry of PLIC and the contralesional non-primary motor cortex activity showed that the greater damaged CST, the greater contralesional non-primary motor cortex recruited. While the negative correlation between them after the FES training indicates that after recovery the non-primary motor cortex plays different role in different stroke phases. Our study demonstrates that functional organization of a residual distributed motor system is related to the degree of disruption to the CST, and the non-primary motor areas plays an important role in motor recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.