ArticlePloS one2013
Do mitochondria limit hot fish hearts? Understanding the role of mitochondrial function with heat stress in Notolabrus celidotus.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 179 citations in OpenAlex.
- Bioenergetics-Driven Extracellular Vesicle Therapies for Heart Failure: From Preclinical Insights to Regenerative Translation.International journal of molecular sciences · 2026Review
- Metabolic Adaptation to Following Temperature Acclimation in Fish on the Yun-Gui Plateau.Biology · 2025Article
- A Double Challenge for Fish: The Combined Stress of Warming and Pharmaceuticals in Aquatic Systems.Journal of xenobiotics · 2025Review
- Antioxidant Defenses in the Kidneys and Heart of the Freshwater Fish Astyanax lacustris Subjected to High (31°C) and Low (15°C) Temperatures.Cell biochemistry and function · 2025Article
- Physiological Responses and Histopathological Changes in Narrow-Clawed Crayfish (Animals : an open access journal from MDPI · 2025Article
- Unraveling the metabolic gene expression and energetic patterns of the seasonally acclimatized gilthead seabream.Fish physiology and biochemistry · 2025Article
- Interactive effects of elevated temperature and venlafaxine on mitochondrial respiration and enzymatic capacity in Nile tilapia (Oreochromis niloticus).Environmental toxicology and chemistry · 2025Article
- Climate change consequences on the systemic heart of female Octopus maya: oxidative phosphorylation assessment and the antioxidant system.Biology open · 2024Article
- An evolving roadmap: using mitochondrial physiology to help guide conservation efforts.Conservation physiology · 2024Article
- Article
- Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Metabolic resilience of the Australasian snapper (Frontiers in physiology · 2023Article
- Metabolic rate increases with acclimation temperature and is associated with mitochondrial function in some tissues of threespine stickleback.The Journal of experimental biology · 2022Article
- Effects of Ultra-High Pressure on Endogenous Enzyme Activities, Protein Properties, and Quality Characteristics of Shrimp (Molecules (Basel, Switzerland) · 2022Article
- Aquaponics as a Promising Strategy to Mitigate Impacts of Climate Change on Rainbow Trout Culture.Animals : an open access journal from MDPI · 2022Review
- Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways.Metabolites · 2022Review
- Can temperature-dependent changes in myocardial contractility explain why fish only increase heart rate when exposed to acute warming?The Journal of experimental biology · 2022Article
- Proteomic analysis of temperature-dependent developmental plasticity within the ventricle of juvenile Atlantic salmon (Current research in physiology · 2022Article
- High resolution respirometry of isolated mitochondria from adult Octopus maya (Class: Cephalopoda) systemic heart.PloS one · 2022Article
- Acute and chronic cold exposure differentially affect cardiac control, but not cardiorespiratory function, in resting Atlantic salmon (SCurrent research in physiology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hearts are the first organs to fail in animals exposed to heat stress. Predictions of climate change mediated increases in ocean temperatures suggest that the ectothermic heart may place tight constraints on the diversity and distribution of marine species with cardiovascular systems. For many such species, their upper temperature limits (Tmax) and respective heart failure (HF) temperature (T(HF)) are only a few degrees from current environmental temperatures. While the ectothermic cardiovascular system acts as an "ecological thermometer," the exact mechanism that mediates HF remains unresolved. We propose that heat-stressed cardiac mitochondria drive HF. Using a common New Zealand fish, Notolabrus celidotus, we determined the THF (27.5°C). Haemoglobin oxygen saturation appeared to be unaltered in the blood surrounding and within heat stressed hearts. Using high resolution respirometry coupled to fluorimeters, we explored temperature-mediated changes in respiration, ROS and ATP production, and overlaid these changes with T(HF). Even at saturating oxygen levels several mitochondrial components were compromised before T(HF). Importantly, the capacity to efficiently produce ATP in the heart is limited at 25°C, and this is prior to the acute T(HF) for N. celidotus. Membrane leakiness increased significantly at 25°C, as did cytochrome c release and permeability to NADH. Maximal flux rates and the capacity for the electron transport system to uncouple were also altered at 25°C. These data indicate that mitochondrial membrane integrity is lost, depressing ATP synthesis capacity and promoting cytochrome c release, prior to T(HF). Mitochondria can mediate HF in heat stressed hearts in fish and play a significant role in thermal stress tolerance, and perhaps limit species distributions by contributing to HF.
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