ArticlePloS one2013
Insights into the evolution of the CSP gene family through the integration of evolutionary analysis and comparative protein modeling.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Odorant-binding proteins and chemosensory proteins in insects: structural insights, functional plasticity, and prospects for targeted pest management.Molecular biology reports · 2026Review
- Ecological Adaptation in the Chemosensory Gene Repertoire of the Safflower Aphid,International journal of molecular sciences · 2025Article
- Review
- Chemosensory protein 4 is required forFrontiers in physiology · 2022Article
- The Crystal Structure of theInsects · 2021Article
- Altered Expression of Chemosensory and Odorant Binding Proteins in Response to Fungal Infection in the Red Imported Fire Ant,Frontiers in physiology · 2021Article
- Identification and motif analyses of candidate nonreceptor olfactory genes of Dendroctonus adjunctus Blandford (Coleoptera: Curculionidae) from the head transcriptome.Scientific reports · 2020Article
- Mechanisms of recognition in birds and social Hymenoptera: from detection to information processing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Expression Profiles and Biochemical Analysis of Chemosensory Protein 3 from Nilaparvata lugens (Hemiptera: Delphacidae).Journal of chemical ecology · 2020Article
- Identification of chemosensory genes from the antennal transcriptome of Semiothisa cinerearia.PloS one · 2020Article
- A Chemosensory ProteinFrontiers in physiology · 2020Article
- Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics.BMC genomics · 2018Article
- Identification of an Alarm Pheromone-Binding Chemosensory Protein From the Invasive Sycamore Lace BugFrontiers in physiology · 2018Article
- Identification, Expression Patterns, and Functional Characterization of Chemosensory Proteins inFrontiers in physiology · 2018Article
- Silencing of Chemosensory Protein Gene NlugCSP8 by RNAi Induces Declining Behavioral Responses ofFrontiers in physiology · 2018Article
- Evolutionary History of Chemosensory-Related Gene Families across the Arthropoda.Molecular biology and evolution · 2017Article
- Evolution, expression and association of the chemosensory protein genes with the outbreak phase of the two main pest locusts.Scientific reports · 2017Article
- Genomic Features of the Damselfly Calopteryx splendens Representing a Sister Clade to Most Insect Orders.Genome biology and evolution · 2017Article
- Chemosensory Gene Families inFrontiers in physiology · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect chemical communication and chemosensory systems rely on proteins coded by several gene families. Here, we have combined protein modeling with evolutionary analysis in order to study the evolution and structure of chemosensory proteins (CSPs) within arthropods and, more specifically, in ants by using the data available from sequenced genomes. Ants and other social insects are especially interesting model systems for the study of chemosensation, as they communicate in a highly complex social context and much of their communication relies on chemicals. Our ant protein models show how this complexity has shaped CSP evolution; the proteins are highly modifiable by their size, surface charge and binding pocket. Based on these findings, we divide ant CSPs into three groups: typical insect CSPs, an ancient 5-helical CSP and hymenopteran CSPs with a small binding pocket, and suggest that these groups likely serve different functions. The hymenopteran CSPs have duplicated repeatedly in individual ant lineages. In these CSPs, positive selection has driven surface charge changes, an observation which has possible implications for the interaction between CSPs and ligands or odorant receptors. Our phylogenetic analysis shows that within the Arthropoda the only highly conserved gene is the ancient 5-helical CSP, which is likely involved in an essential ubiquitous function rather than chemosensation. During insect evolution, the 6-helical CSPs have diverged and perform chemosensory functions among others. Our results contribute to the general knowledge of the structural differences between proteins underlying chemosensation and highlight those protein properties which have been affected by adaptive evolution.
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