ArticlePatient preference and adherence2013
Nonadherence in difficult asthma - facts, myths, and a time to act.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- 2024 Update on Position Statement by Experts from the Polish Society of Allergology and the Polish Respiratory Society on the Evaluation of Efficacy and Effectiveness of Single Inhaler Triple Therapies in Asthma Treatment.Advances in respiratory medicine · 2024Guideline
- Sanfu acupoint herbal patching for stable asthma: A systematic review and meta-analysis of randomised controlled trials.Complementary therapies in medicine · 2017Pooled it
- Inhaler adherence, associated factors and outcomes among adult asthma patients in Singapore.Singapore medical journal · 2026Article
- Targeted self-directed learning can support clinicians to improve patient adherence to inhaled corticosteroid therapy in asthma.BMJ open respiratory research · 2025Article
- Enhancing severe asthma care: real-world outcomes of a digital adherence and self-management platform.ERJ open research · 2025Article
- A case scenario study on adherence to GINA recommendations by primary care physicians in an area of Southern Italy: the "Progetto Padre 2.0".BMC primary care · 2025Observational
- Asthma prescribing trends, inhaler adherence and outcomes: a Real-World Data analysis of a multi-ethnic Asian Asthma population.NPJ primary care respiratory medicine · 2024Article
- Does inhaler adherence really matter in severe asthma?Breathe (Sheffield, England) · 2024Review
- Determining Adherence to Inhaled Corticosteroids From the Epic Electronic Medical Record.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Clinical outcomes of children using a metered dose inhaler with a sleeve attachment device to improve ease of use.The journal of allergy and clinical immunology. Global · 2023Article
- Emerging Roles of Malaysian Pharmacists in Asthma Management Amidst the COVID-19 Pandemic: A Narrative Review.The Malaysian journal of medical sciences : MJMS · 2023Review
- Nonadherence to antiasthmatic medications and its predictors among asthmatic patients in public hospitals of Bahir Dar City, North West Ethiopia: using ASK-12 tool.Asthma research and practice · 2023Article
- Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems.Nature reviews. Drug discovery · 2023Review
- Co-Developing Patient-Centered Information: A Focus Group Study of Asthma Patients' Preferences and Attitudes towards New Medical Treatment Guidelines.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- A Shift in Asthma Treatment According to New Guidelines: An Evaluation of Asthma Patients' Attitudes towards Treatment Change.International journal of environmental research and public health · 2023Article
- The emerging role of digital health in the management of asthma.Therapeutic advances in chronic disease · 2023Review
- Article
- A response to COVID-19 school closures: The feasibility of a school-linked text message intervention as an adaptation to school-supervised asthma therapy.Pediatric pulmonology · 2022Article
- Severe asthma in children: An official statement from Saudi Pediatric Pulmonology Association.Saudi medical journal · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonadherence to prescribed treatment is an important cause of difficult asthma. Rates of nonadherence amongst asthmatic patients have been shown to range between 30% and 70%. This is associated with poor health care outcomes and increased health care costs. There is no such thing as a "typical" nonadherent patient. The reasons driving nonadherence are multifactorial. Furthermore, adherence is a variable behavior and not a trait characteristic. Adherence rates can vary between the same individual across treatments for different conditions. There is no consistent link between socioeconomic status and nonadherence, and although some studies have shown that nonadherence is more common amongst females, this is not a universal finding. The commonly held perception that better adherence is driven by greater disease severity has been demonstrated to not be the case, in both pediatric and adult patients. Identification of nonadherence is the first step. If adherence is not checked, it is likely that poor adherence will be labeled as refractory disease. Failure to identify poor adherence may lead to inappropriate escalation of therapy, including the potential introduction of complex biological therapies. Surrogate measures, such as prescription counting, are not infallible. Nonadherence can be difficult to identify in clinical practice, and a systematic approach using a variety of tools is required. Nonadherence can be successfully addressed. Therefore, assessment of adherence is of paramount importance in difficult asthma management, in order to reduce exacerbations and steroid-related side effects as well as hospital and intensive care admissions, health care cost, and inappropriate treatment escalation. In this paper, we present an overview of the literature surrounding nonadherence in difficult asthma. We explore the facts and myths surrounding the factors driving nonadherence as well as how it can be identified and addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.