ArticleArteriosclerosis, thrombosis, and vascular biology2013
Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Hypoalbuminemia increases fibrin clot density and impairs fibrinolysis.Journal of thrombosis and haemostasis : JTH · 2026Article
- A single amino acid substitution in Fibronectin Binding protein A (FnBPA) governs Staphylococcus aureus virulence via host transglutaminase-mediated fibrin crosslinking.PLoS pathogens · 2025Article
- Plasminogen activation and plasmin activity are not necessary to prevent venous thrombosis/thromboembolism.Blood · 2025Observational
- Effects of Prothrombin on Podocytopathy and Proteinuria in Glomerular Disease.Journal of the American Society of Nephrology : JASN · 2025Article
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- An in situ inferior vena cava ligation-stenosis model to study thrombin generation rates with flow.Thrombosis journal · 2022Article
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- Novel venous thromboembolism mouse model to evaluate the role of complete and partial factor XIII deficiency in pulmonary embolism risk.Journal of thrombosis and haemostasis : JTH · 2021Article
- Visualizing thrombosis to improve thrombus resolution.Research and practice in thrombosis and haemostasis · 2021Article
- Injury measurements improve interpretation of thrombus formation data in the cremaster arteriole laser-induced injury model of thrombosis.Journal of thrombosis and haemostasis : JTH · 2020Article
- Model-dependent contributions of FXII and FXI to venous thrombosis in mice.Journal of thrombosis and haemostasis : JTH · 2020Article
- The factor XIII-A Val34Leu polymorphism decreases whole blood clot mass at high fibrinogen concentrations.Journal of thrombosis and haemostasis : JTH · 2020Article
- Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.Blood · 2019Article
- Fibrinogen and factor XIII: newly recognized roles in venous thrombus formation and composition.Current opinion in hematology · 2018Review
- Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice.Blood advances · 2018Article
- Fibrinogen and Fibrin in Hemostasis and Thrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
- New findings on venous thrombogenesis.Hamostaseologie · 2017Review
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- Assessment of Venous Thrombosis in Animal Models.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIndividuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of this study were to determine the pathological role of elevated prothrombin in venous and arterial thrombosis in vivo, and distinguish thrombogenic mechanisms in these vessels. APPROACH AND
resultsProthrombin was infused into mice to raise circulating levels. Venous thrombosis was induced by electrolytic stimulus to the femoral vein or inferior vena cava ligation. Arterial thrombosis was induced by electrolytic stimulus or ferric chloride application to the carotid artery. Mice infused with prothrombin demonstrated increased tissue factor-triggered thrombin generation measured ex vivo, but did not have increased circulating prothrombotic biomarkers in the absence of vessel injury. After venous injury, elevated prothrombin increased thrombin generation and the fibrin accumulation rate and total amount of fibrin ≈ 3-fold, producing extended thrombi with increased mass. However, elevated prothrombin did not accelerate platelet accumulation, increase the fibrin accumulation rate, or shorten the vessel occlusion time after arterial injury.
conclusionsThese findings reconcile previously discordant findings on thrombin generation in hyperprothrombinemic individuals measured ex vivo and in vitro, and show elevated prothrombin promotes venous, but not arterial, thrombosis in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.