ArticleJournal of fluorescence2013
Spectrofluorimetric determination of terbinafine hydrochloride and linezolid in their dosage forms and human plasma.
Article in Journal of fluorescence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects.Molecules (Basel, Switzerland) · 2021Review
- Factorial design-assisted reversed phase-high performance liquid chromatography method for simultaneous determination of fluconazole, itraconazole and terbinafine.Royal Society open science · 2021Article
- Investigating the interaction of terbinafine with xanthenes dye for its feasible determination applying the resonance Rayleigh scattering technique.Royal Society open science · 2021Article
- Combining derivative and synchronous approaches for simultaneous spectrofluorimetric determination of terbinafine and itraconazole.Royal Society open science · 2020Article
- Analytical methods for determination of terbinafine hydrochloride in pharmaceuticals and biological materials.Journal of pharmaceutical analysis · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of Terbinafine HCl (TRH) and linezolid (LNZ) in their pharmaceutical formulations. The proposed method is based on measuring the native fluorescence of the studied drugs in water at 336 nm after excitation at 275 nm for TRH and 375 nm after excitation at 254 nm for LNZ. The fluorescence-concentration plots were rectilinear over the range of 0.02-0.15 μg/mL for TRH and 0.5-5.0 μg/mL for LNZ. With lower detection limits of 3.0 and 110.0 ng/mL and a lower quantification limit of 9.0 and 320.0 ng/mL for TRH and LNZ, respectively. The method was successfully applied to the analysis of TRH in its commercial tablets, cream, gel and spray formulations and the results were in good agreement with those obtained with the official method. In addition the method was also applied to the analysis of LNZ in its capsule and I.V solution and the results were in good agreement with those obtained with the comparison method. The effect of sensitizers was studied. The method was extended to the determination of the studied drugs in spiked human plasma and the results were satisfactory.
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Registered trials
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