ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Nocturnal bilevel positive airway pressure for the treatment of asthma.Respiratory physiology & neurobiology · 2020Trial
- Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?Respiratory research · 2023Review
- Airway smooth muscle adapting in dynamic conditions is refractory to the bronchodilator effect of a deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.Journal of engineering and science in medical diagnostics and therapy · 2019Article
- A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.Biomechanics and modeling in mechanobiology · 2018Article
- Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.Biophysical journal · 2018Article
- Article
- Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- No effect of elevated operating lung volumes on airway function during variable workrate exercise in asthmatic humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Airway hyperresponsiveness; smooth muscle as the principal actor.F1000Research · 2016Review
- Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- MATHEMATICAL MODELING OF VENTILATION DEFECTS IN ASTHMA.Drug discovery today. Disease models · 2015Article
- Nonlinear compliance modulates dynamic bronchoconstriction in a multiscale airway model.Biophysical journal · 2014Article
- Pharmacological bronchodilation is partially mediated by reduced airway wall stiffness.British journal of pharmacology · 2014Article
- Emergence of airway smooth muscle mechanical behavior through dynamic reorganization of contractile units and force transmission pathways.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways.PloS one · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
Fluctuating forces imposed on the airway smooth muscle due to breathing are believed to regulate hyperresponsiveness in vivo. However, recent animal and human isolated airway studies have shown that typical breathing-sized transmural pressure (Ptm) oscillations around a fixed mean are ineffective at mitigating airway constriction. To help understand this discrepancy, we hypothesized that Ptm oscillations capable of producing the same degree of bronchodilation as observed in airway smooth muscle strip studies requires imposition of strains larger than those expected to occur in vivo. First, we applied increasingly larger amplitude Ptm oscillations to a statically constricted airway from a Ptm simulating normal functional residual capacity of 5 cmH2O. Tidal-like oscillations (5-10 cmH2O) imposed 4.9 ± 2.0% strain and resulted in 11.6 ± 4.8% recovery, while Ptm oscillations simulating a deep inspiration at every breath (5-30 cmH2O) achieved 62.9 ± 12.1% recovery. These same Ptm oscillations were then applied starting from a Ptm = 1 cmH2O, resulting in approximately double the strain for each oscillation amplitude. When extreme strains were imposed, we observed full recovery. On combining the two data sets, we found a linear relationship between strain and resultant recovery. Finally, we compared the impact of Ptm oscillations before and after constriction to Ptm oscillations applied only after constriction and found that both loading conditions had a similar effect on narrowing. We conclude that, while sufficiently large strains applied to the airway wall are capable of producing substantial bronchodilation, the Ptm oscillations necessary to achieve those strains are not expected to occur in vivo.
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