Observational studyInternational journal of clinical pharmacy2013
Adverse drug events in surgical patients: an observational multicentre study.
Observational study in International journal of clinical pharmacy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Medication Management of Patients With Cancer Undergoing Surgery From Preadmission to Discharge: A Mixed-Methods Systematic Review.Journal of advanced nursing · 2025Pooled it
- Preventable medication harm across health care settings: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Pooled it
- The prevalence of medication-related adverse events in inpatients-a systematic review and meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- An individual patient data meta-analysis on factors associated with adverse drug events in surgical and non-surgical inpatients.British journal of clinical pharmacology · 2015Pooled it
- Medication Discrepancy-Related Medication Safety Incidents in Surgical Patients: A Register Study Based on Medication Safety Incident Reports.Health science reports · 2026Article
- Article
- Observational
- Incidence of adverse drug events in patients hospitalized in the medical wards of a teaching referral hospital in Ethiopia: a prospective observational study.BMC pharmacology & toxicology · 2022Observational
- Medication-related adverse events in health care-what have we learned? A narrative overview of the current knowledge.European journal of clinical pharmacology · 2022Review
- Impact of Pharmacist-Directed Medication Reconciliation in Reducing Medication Discrepancies: A Randomized Controlled Trial.The Canadian journal of hospital pharmacy · 2022Article
- MicroCT optimisation for imaging fascicular anatomy in peripheral nerves.Journal of neuroscience methods · 2020Article
- Avoiding off-target effects in electrical stimulation of the cervical vagus nerve: Neuroanatomical tracing techniques to study fascicular anatomy of the vagus nerve.Journal of neuroscience methods · 2019Review
- Categorization and association analysis of risk factors for adverse drug events.European journal of clinical pharmacology · 2018Review
- A multifaceted intervention to reduce drug-related complications in surgical patients.British journal of clinical pharmacology · 2017Article
- Evidence based development of bedside clinical drug rules for surgical patients.International journal of clinical pharmacy · 2014Article
- Quality of pharmaceutical care in surgical patients.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErrors occurring during different steps of the medication process can lead to adverse drug events (ADEs). Surgical patients are expected to have an increased risk for ADEs during hospitalization. However, detailed information about ADEs in the surgical patient is lacking.
objectiveIn this study, we aim to measure the incidence and nature of (preventable) ADEs, potential risk factors for and outcome parameters of (preventable) ADEs in surgical patients.
settingObservational multicentre cohort study in which eight surgical wards participated from three Dutch hospitals, all using computerized physician order entry (CPOE) systems with clinical decision support.
methodsElectively admitted surgical patients of the participating wards were included from March until June 2009. ADEs were measured using a standardized method with expert judgment. Incidence, severity, preventability and accountable medication were assessed. Poisson regression analysis was applied to determine the associations between possible risk factors and the occurrence of ADEs, expressed as incidence rate ratio (IRR). Also outcomes of ADEs in surgical patients were measured.
main outcome measureThe incidence and nature of (preventable) ADEs in surgical patients.
resultsA total of 567 surgical patients were included. We found an incidence of 27.5 ADEs and 4.2 preventable ADEs (pADEs) per 100 admissions (15.4 %). A quarter of the pADEs were severe or life-threatening. Opioids and anti-coagulation medication play a major role in the occurrence of ADEs and pADEs respectively. Univariate analysis revealed an American Society of Anesthesiologists classification of III or more as a risk factor for ADEs. Patients older than 65 years [IRR 2.77 (1.14-6.72)], with cardiovascular comorbidity [IRR 2.87 (1.13-7.28)], or undergoing vascular surgery [IRR 2.32 (1.01-5.32)] were at risk for pADEs. Patients experiencing an ADE had a significant longer duration of admission than patients without an ADE.
conclusionsSurgical patients are at considerable risk of experiencing one or more ADEs during their admission, also in CPOE-hospitals. Risk factors for pADEs are age older than 65 years, cardiovascular comorbidity, and vascular surgery. Intensified monitoring may be needed in patients with a higher than average risk for pADEs.
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